The emergence of we-media provides a new life and learning platform for college students, which is beneficial to the college students' knowledge acquisition and development of individual character. However, it also challenges the traditional mode of ideological and political education, weakening the influence of the discourse ideological and political education, and the mainstream ideology. Facing these new challenges, determine to better carry out ideological and political education in the new era, colleges and universities must innovate the mode of ideological and political education, enhance the discourse power of ideological and political education and strengthen the ideological construction of colleges and universities in the we-media era.