In the current context, the society pays more attention to vocational education, requiring technical colleges to cultivate a group of high-quality skilled talents with solid theory, strong professional ability and good professional quality. With the rapid development of laser technology, more detailed requirements are put forward for the training of laser technology application professionals. In order to meet the current situation of social development and realize the comprehensive development of talents in many aspects, technical colleges can introduce the production study research mode in the cultivation of laser technology application talents, and promote the teaching development with the help of new teaching methods, so as to fully guarantee the students' future employment and further study. This paper explores the innovation and practice of laser technology application talents training under the background of industry university research, and puts forward relevant views, in order to improve the teaching effect and realize the win-win situation between school and enterprise.