In the current science teaching in vocational colleges, basic medicine and clinical medicine play an important role in cultivating students' career development. They are the key courses to strengthen students' comprehensive ability and improve students' application skills. However, in the current internal medicine teaching, there is a problem that the combination of the two teaching is not close, which leads to some difficulties in learning. Under this background, this paper analyzes the current situation of science teaching in vocational colleges, and then puts forward the effective path of the combination of basic medicine and clinical medicine teaching.