Outcome-based Education is a kind of ability-oriented education mode, which is oriented by social needs and focuses on cultivating students' ability to solve practical problems. All aspects of this education mode are designed and implemented closely around students. Taking the teaching of database principle and application course as an example, aiming at a series of problems existing in the current course teaching, taking OBE education concept as the main teaching reform guiding strategy, this paper puts forward a series of reform measures and solutions from the aspects of teaching goal formulation, teaching content optimization, teaching methods innovation, experimental design optimization, evaluation system innovation, etc.