Psychological health education has been highly valued by the party and the state. During the fight against the COVID-19, colleges and universities have made a beneficial exploration in carrying out psychological health education. In older to further understand the impact of the epidemic on the psychological health of college students, a survey was carried out based on questionnaire survey, depth interview and expert consultation. The survey found that the epidemic increased the psychological pressure and posed new challenges to the psychological health education in colleges and universities. Based on the analysis of the causes from the four aspects of society, family, college and individual, this thesis put forwards some suggestions on how to effectively carry out the psychological health education of college students in the context of fighting against the epidemic.