Now it is the digital information age. With the maturity of mobile Internet technology and the increase of online education demand, mobile learning applications based on mobile Internet terminals have been vigorously developed and widely used. Blended English teaching based on mobile network technology has become an inevitable trend in College English teaching. The new teaching mode is student-centered and emphasizes the interaction between teachers and students. The implementation of personalized teaching mode is conducive to improving students' learning autonomy and innovation, it can improve the classroom teaching effect to a certain extent. At present, the post-90s college students are the pioneers of the Internet era, but also the trendsetters in the wave of mobile Internet. How to effectively apply the mobile learning platform such as MosoTeach to College English teaching is the core theme of this paper.