With the rapid development of the manufacturing industry, work safety issues in the manufacturing industry have also begun to enter people’s vision, and job fatigue is one of the important influencing factors. To explore the influencing factors of occupational fatigue among online workers in manufacturing enterprises, subjective questionnaire surveys and field observations were used to collect research sample data. SPSS 26.0 software was used to analyze the validity of the obtained sample data, and five influencing factors were extracted: operators, the work itself, the work environment, work equipment, and enterprise management. A structural equation model of the influencing factors of occupational fatigue among online workers in manufacturing enterprises was constructed, and AMOS 24.0 software was used for factor analysis. The research results show that the degree of impact on job fatigue of online workers in the manufacturing industry is in the following order: work environment (B)>work equipment (F)>enterprise management (M)>work itself (O)>work personnel (D). Finally, propose targeted policy recommendations based on the degree of impact.
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