To promote the harmonious development of economic globalization, China has put forward the initiative of new international relations, giving full attention to China’s role as a big country and developing new international relations. In the context of new international relations, South-South cooperation is facing new opportunities and challenges. The rise and development of South-South cooperation in developing countries is a new era experience and a global resource development plan. Not only does South-South cooperation emphasize respect for national internal affairs and mutual benefit in global development, but it also maintains the development of globalization in the context of new international relations. This paper analyzes the trend and factors of South-South cooperation in the context of new international relations.