Keywords
CiteSpace
Bone age
Growth and development
Sex hormones
Constitution of traditional Chinese medicine
Submitted : 2025-12-16
Accepted : 2025-12-31
Published : 2026-01-15
Abstract
Objective: To review the scientific research results of early puberty in children in the past decade, and to explore the current status, hot spots and frontiers of research in the field of early puberty in children. Methods: From January 1, 2014 to April 30, 2024, literature on early puberty in children was retrieved from CNKI database and Web of Science (WOS) core collection. CiteSpace6.3. R1 software was used for bibliometric analysis of authors, institutions and key words, and related visual maps were drawn. Results: A total of 1548 English literatures and 1113 Chinese literatures were included. The number of published papers in both Chinese and English showed an increasing trend. The authors of the high production in Chinese were Ye Jin and Yang Li, and the high production institutions were the pediatrics department of Hubei University of Chinese Medicine and Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine. The authors are Latronico, Ana Claudia, and Universidade de Sao Paulo. Hot topics in Chinese and English studies include bone age, hormones, genetic inheritance, the correlation between precocious puberty and obesity and short stature. Conclusion: There is an increasing trend of research in the field of early puberty in children. The research on physical identification of children with precocious puberty and the dynamic detection of precocious puberty, height and obesity by Internet is worthy of continuous attention by domestic scholars.
References
Liu X, Wang K, Wang J, et al., 2019, Research Progress on the Relationship Between Vitamin D Deficiency and Central Precocious Puberty in Children. Chinese Journal of Child Health, 32(01): 59–63.
Yu J, Sun W, Sun Y, 2024, Diagnosis and Treatment Guide of Integrated Chinese and Western Medicine for Children with Precocious Puberty (2023 Edition). Journal of Traditional Chinese Medicine, 65(05): 546–552.
Lei E, Bai S, Huang T, et al., 2024, Analysis of Animal Model of Central Precocious Puberty Based on Clinical Characteristics of Chinese and Western Medicine. Clinical Pharmacology of Chinese Medicine, 1–9.
Wang F, 2021, Promoting the Healthy Growth of Children and Sustainable Development of Society: Interpretation of “Children and Health” in the Outline for the Development of Children in China (2021–2030). China’s Maternal and Child Health Journal, 12(6): 1–4.
Yang L, Yang Y, Lu Q, et al., 2024, Resistance Precocious Medicinal Broth for the Treatment of Simple Early Breast Development in Girls. Journal of Practical Clinical Medicine, 25(01): 50–54.
Yang Y, Gong X, Lu Q, et al., 2020, Correlation Between Environmental Endocrine Disruptors and Simple Early Breast Development in Infants. Chinese Practical Journal of Pediatrics, 35(5): 379–382.
Canton A, Tinano F, Guasti L, et al., 2023, Rare Variants in the MECP2 Gene in Girls with Central Precocious Puberty: A Translational Cohort Study. The Lancet Diabetes & Endocrinology, 11(8): 545–554.
Machado C, Eduardo S, Ribeiro M, et al., 2024, The Genetic Etiology Is a Relevant Cause of Central Precocious Puberty. European Journal of Endocrinology, 6.
Ding Y, Wang H, Bao M, et al., 2023, New Diagnosis and Treatment of Idiopathic Central Precocious Puberty in Children. Science and Technology Review, 41(20): 89–96.
Lu Y, Chen L, 2024, Meta-analysis of Efficacy and Safety of GnRHa Combined with GH in the Treatment of Central Precocious Puberty in Girls. Chinese Journal of Hospital Pharmacy, 1–8.
Lan Y, Yuan Y, Zong M, et al., 2024, Differentiation and Treatment of Precocious Puberty in Chinese Medicine from Constitution Bias. World of Chinese Medicine, 19(09): 1355–1358.
Li J, Shi D, Liu Y, et al., 2023, Research Hotspots and Trends in Adolescent Development Among Children and Adolescents From 2013 to 2022. Chinese School Health, 44(06): 900–905.
Aiello F, Palumbo S, Cirillo G, et al., 2024, MKRN3 Circulating Levels in Girls with Central Precocious Puberty Caused by MKRN3 Gene Mutations. Journal of Endocrinological Investigation, 47(6): 1477–1485.
Li J, Shi D, Liu Y, et al., 2023, Research Hotspots and Trends in Adolescent Development Among Children and Adolescents From 2013 to 2022. Chinese School Health, 44(06): 900–905.
He X, Wen J, Zheng M, et al., 2019, Application Value of Pelvic Ultrasound in the Evaluation of Uterine Development in Girls. Chinese Journal of Ultrasound Medicine, 40(06): 683–685.
Wang Y, Tian L, Kong Q, et al., 2024, Relationship Between Vitamin D Deficiency and Central Precocious Puberty in Girls. China’s Maternal and Child Health Care, 33(17): 3446–3449.
Shen Q, Yu M, Gao P, 2019, Efficacy and Safety of Triprerelin in the Treatment of Central Precocious Puberty in Girls. Chinese Journal of Modern Applied Pharmacy, 40(22): 3141–3145.
Xiong Y, Cheng M, Xu K, 2019, Expert Consensus on Diagnosis and Treatment of Central Precocious Puberty (2022). Journal of Practical Obstetrics and Gynecology, 39(06): 422–424.
Yuan J, Wang X, Cui Y, et al., 2024, Urine Luteinizing Hormone Application in the Prediction of Central Precocious Puberty in Girls. Journal of Peking University (Medical Edition), 56(5): 788–793.
Zhou F, Zhao J, Song Q, et al., 2019, Research Progress on the Treatment of Idiopathic Precocious Puberty in Girls by Traditional Chinese Medicine. Chinese Pediatrics of Integrated Traditional and Western Medicine, 16(01): 19–22.
Jiang M, Dong W, Mo S, 2023, Research Progress of TCM Syndrome Distribution and Physical Characteristics in Children with Precocious Puberty. Journal of Hebei Traditional Chinese Medicine, 45(07): 1195–1198.
Shu G, Tang M, Huang Y, 2021, Application of an Internet-Based Height Intervention Model in Children with Short Stature. Chinese Journal of Continuing Medical Education, 13(36): 132–136.
Zhang J, 2022, Factors Influencing the Occurrence of Precocious Puberty in Obese Children. Clinical Medicine, 42(09): 35–37.
Cui Y, Tang W, Hu S, 2024, Treatment of Idiopathic Dwarfism with Integrated Chinese and Western Medicine. Journal of Medical Theory and Practice, 5(8): 1308–1310.
Ghosh H, Rai S, Manzar M, et al., 2022, Differential Expression and Interaction of Melatonin and Thyroid Hormone Receptors with Estrogen Receptor α Improve Ovarian Functions in Letrozole-Induced Rat Polycystic Ovary Syndrome. Life Sciences, 295: 120086.
Jiang W, Ying J, Chen J, 2023, Expression of Estradiol, Insulin-Like Growth Factor Binding Protein-3, and Leptin in Girls with Central Precocious Puberty and Their Correlation with Environmental Endocrine Disruptors. Maternal and Child Health Care in China, 38(24): 4828–4831.
Yang H, Ge A, Xie H, et al., 2022, Effects of Ambient Air Pollution on Precocious Puberty: A Case-Crossover Analysis in Nanjing, China. Journal of Clinical Medicine, 12(1): 282.
Calcaterra V, Cena H, Loperfido F, et al., 2024, Evaluating Phthalates and Bisphenol in Foods: Risks for Precocious Puberty and Early-Onset Obesity. Nutrients, 16(16): 2732.
Gao Y, Gan L, Cao S, et al., 2022, Analysis of Disease Types of Hospitalized Children During the Novel Coronavirus Pneumonia Epidemic in a Grade III General Hospital in Shanghai. Journal of Naval Medical University, 43(04): 406–413.
Zhu Q, Liu Y, 2023, Adolescent Intestinal Flora Characteristics and Gender Dimorphism: Research Progress. Chinese School Health, 44(11): 1752–1760.
Yue M, Zhang L, 2024, Exploring the Mechanistic Interplay Between Gut Microbiota and Precocious Puberty: A Narrative Review. Microorganisms, 12(2): 323.
Zhang Y, Luo F, 2019, Recent Progress in the Etiology of Central Precocious Puberty Caused by Genetic Defects. Chinese Journal of Contemporary Pediatrics, 26(03): 302–307.
Okamoto N, Yoshida S, Ogitani A, et al., 2024, Biallelic Loss-of-Function Variants of EZH1 Cause a Novel Developmental Disorder with Central Precocious Puberty. American Journal of Medical Genetics Part A, e63726.