Keywords
Conventional therapy
Chronic obstructive pulmonary disease
Respiratory failure
Clinical effect
Submitted : 2024-01-27
Accepted : 2024-02-11
Published : 2024-02-26
Abstract
Objective: To explore the clinical effect of a non-invasive ventilator combined with conventional therapy in the treatment of patients with chronic obstructive pulmonary disease (COPD) combined with respiratory failure. Methods: 68 patients with COPD combined with respiratory failure treated in our hospital from September 2021 to October 2023 were selected as the research subjects. Using the random number table method, they were divided into a control group and an experimental group of 34 cases each. The control group received conventional symptomatic treatment, and the experimental group received non-invasive ventilator treatment based on the control group. The clinical effects, blood gas indicators (partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2)), lung function (forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), 6 min walking distance), complications, and inflammatory factor levels (c-reactive protein (CRP), interleukin-6 (IL-6), neutrophil-to- lymphocyte ratio (NLR)) of the two groups of patients were observed. Results: (1) The clinical efficacy of the patients in the experimental group (33/97.06%) was more significant as compared with the control group (25/73.53%) (P < 0.05); (2) After treatment, the clinical efficacy of the two groups of patients in terms of FEV1, FEV1 /FVC, 6-minute walking distance, PaO2 and SaO2 all increased in the experimental group as compared to that of the control group (P < 0.05); (3) After treatment, the PaCO2, CRP, IL-6, and NLR of the two groups of patients decreased, and the decrease in the experimental group was higher than that of the control group (P < 0.05); (4) The patients’ complication rate in the experimental group (2/5.88%) was lower as compared to that of the control group (9/26.46%) (P < 0.05). Conclusion: Non-invasive ventilators combined with conventional therapy achieved good clinical results in treating patients with COPD and respiratory failure.
References
Zhang W, 2023, Clinical Effect of Non-Invasive Ventilator in Treating Patients with Type II Respiratory Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese Community Physicians, 39(24): 38–40.
Zhou Y, Zheng Y, 2021, Observation on the Clinical Efficacy and Safety of Non-Invasive Ventilator Combined with Oxygen-Driven Atomization Inhalation in Treating Patients with Chronic Obstructive Pulmonary Disease and Respiratory Failure. Guizhou Medicine, 45(3): 376–378.
Li Y, Wen Y, Tang W, 2017, Observation on the Efficacy of Non-Invasive Ventilator Combined with Oxygen-Driven Aerosol Inhalation in Treating Patients with COPD and Respiratory Failure. Shaanxi Medical Journal, 46(8): 1095– 1096.
Dai H, Liu K, 2019, Observation on the Application Effect of Non-Invasive Positive Pressure Ventilation Combined with Conventional Treatment in Patients with Chronic Obstructive Pulmonary Disease Complicated by Respiratory Failure. Primary Medicine Forum, 23(13): 1848–1849.
Tian X, Ma L, Du G, 2023, Observation on the Efficacy of Non-Invasive Positive Pressure Ventilation and Nasal High-Flow Oxygen Therapy in Treating Elderly Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure. Doctors, 8(3): 57 –60.
Tu M, 2023, Observation on the Efficacy of Non-Invasive Ventilator in Treating Chronic Obstructive Pulmonary Disease Combined with Respiratory Failure. Chinese Practical Medicine, 18(13): 36–39.
Qin D, 2023, Clinical Study on Non-Invasive Positive Pressure Ventilation in Treating Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure. Famous Doctors, 2023(10): 48–50.
Song D, Qiu X, Zhang B, et al., 2021, Observation on the Efficacy and Safety of Nasal High-Flow Oxygen Therapy and Non-Invasive Positive Pressure Ventilation in Treating Elderly Chronic Obstructive Pulmonary Disease Combined with Type II Respiratory Failure. Guizhou Medicine, 45 (8): 1250–1251.
Nie Y, Zhang T, Wang Z, 2019, The Efficacy of a Non-Invasive Ventilator Combined with Salmeterol and Fluticasone Powder Inhalation in Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated by Respiratory Failure and its Impact on Patient Prognosis and Quality of Life. Chinese Drug and Clinical, 19(8): 1229– 1231.
Wang Y, 2023, The Value of Non-Invasive Ventilator in Treating Chronic Obstructive Pulmonary Disease Combined with Respiratory Failure. Smart Health, 9(4): 149–153.
Gao Y, 2017, A Randomized Parallel Controlled Study of Ditan Decoction Combined with Conventional Therapy in Treating Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure. Journal of Practical Traditional Chinese Medicine, 31(10): 61–64.
Hou X, 2013, Progress in Clinical Observation of Traditional Chinese Medicine Combined with Non-Invasive Ventilation in Treating Respiratory Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese Pharmacoeconomics, 2013(3): 434–435.
Qin J, 2023, Observation on the Effect of Non-Invasive Ventilator Combined with Conventional Therapy in Treating
Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure. Chinese Community Physicians, 39(29): 71–73.
Pang J, 2017, Observation on the Efficacy of Non-Invasive Ventilators in Treating Patients with Chronic Obstructive Pulmonary Disease and Respiratory Failure [J]. Medical Equipment, 30(22): 100–101.
Ding Y, 2019, Study on the Effectiveness of Non-Invasive Ventilators in Treating Chronic Obstructive Pulmonary Disease Combined with Respiratory Failure. Chinese Continuing Medical Education, 11(9): 59–61.