Keywords
Low-dose Betaloc
Amiodarone
Clinical effect
Treatment
Submitted : 2023-12-19
Accepted : 2024-01-03
Published : 2024-01-18
Abstract
Objective: To explore and analyze the clinical effect of low-dose Betaloc combined with amiodarone in treating ventricular arrhythmia. Methods: 70 patients with ventricular arrhythmia who were admitted to the Department of Cardiology of our hospital between August 2022 and August 2023 were selected as research subjects. They were divided into two groups using the coin-tossing method: the combination group (n = 35) and the reference group (n = 35). The combination group was treated with low-dose Betaloc and amiodarone, and the control group was treated with low-dose Betaloc alone. The treatment efficacy, cardiac function indicators, and related tested indicators of the two groups were compared. Results: The total efficacy of the treatment received by the combination group was much higher than that of the control group (P < 0.05). Besides, after treatment, the cardiac function indicators such as left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), and cardiac index (CI) of the patients in the combination group were significantly better than those of the reference group (P < 0.05). Furthermore, the high-sensitivity C-reactive protein (Hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), adiponectin (APN), and other related test indicators of the patients in the combination group were significantly better than those of the reference group (P < 0.05). Conclusion: Low-dose Betaloc combined with amiodarone has a noticeable effect in treating ventricular arrhythmia and deserves to be widely promoted.
References
Shen W, Wu O, Yang Z, 2022, The Efficacy of Yangxin Dingpai Capsule Combined with Skin Acupuncture in Treating Tachyarrhythmia of Coronary Heart Disease and its Effect on Heart Rate Variability and Serum Inflammatory Factor Levels. World Traditional Chinese and Western Medicine Binding Magazine, 17(03): 556–560.
Xiao X, 2022, The Relationship Between Serum Interleukin-17 and Tumor Necrosis Factor-? Levels and the Prognosis of Bipolar Radiofrequency Ablation in Patients with Ventricular Arrhythmias. Journal of Chronic Diseases, 23(03): 465–467.
Zhang W, Feng J, Yu Y, et al., 2022, Report on the Response of Patients with Obstructive Sleep Apnea-Hypopnea Syndrome Combined with Nocturnal Arrhythmias to Non-Invasive Ventilation Treatment. World Journal of Sleep Medicine, 9(01): 6–9.
Lai G, Tian T, He Y, et al., 2021, Effects of Cardiac Resynchronization Therapy on Cardiac Function and Adverse Events in Patients with Heart Failure Caused by Arrhythmia. Clinical Medical Research and Practice, 6(31): 82–84.
Wang J, Zhao D, Wang Y, et al., 2021, Research Progress on Types, Mechanisms, Electrocardiogram Prediction, And Continuous Favorable Airway Pressure Treatment of OSA-Related Malignant Arrhythmias. Shandong Medicine, 61(21): 106–110.
Lu J, Zhao Z, 2021, Analysis of the Clinical Efficacy of Creatine Phosphate Sodium Combined with Amiodarone, Deacetyllanosin, and Non-Invasive Ventilator in Treating Patients with Acute Heart Failure Combined with Tachyarrhythmia. Clinical Medical Engineering, 28(07): 941–942.
Zhang M, Liu H, Tang R, 2021, Effects of Corrected Tp-Te Interval, QT Interval, and Tp-Te/QT Ratio on Malignant Arrhythmias After Thrombolytic Treatment in Patients with Acute ST-Segment Elevation Myocardial Infarction. Predictive Value of Adverse Prognosis. Chinese Medicine, 16(01): 33–37.
Bi Z, 2020, Effect of Esmolol on Electrocardiogram QT Dispersion and Malignant Ventricular Arrhythmias in Patients with Acute Anterior Wall Myocardial Infarction During Coronary Intervention. Chinese Practical Medicine, 15(11): 89–91.
Li S, 2020, Analysis of the Clinical Efficacy and Safety Evaluation of the Combination of Wenxin Granules and Metoprolol in Treating Coronary Heart Disease Complicated with Arrhythmia. Electronic Journal of Cardiovascular Diseases Integrated Traditional Chinese and Western Medicine, 8(04): 32.
Wei C, Ren C, Zhuang H, et al., 2020, Analysis of the Correlation Between Arrhythmia and Heart Rate Variability Changes Before and After Interventional Treatment for Congenital Heart Disease and Postoperative Cardiac Function. Chinese Medical Journal, 55(02): 159–162.
Zhu D, Xu S, Liu H, et al., 2019, Study on the Efficacy, Cardiac Function, and Inflammatory Factor Levels of Combined Treatment of Two Drugs on Myocardial Infarction Complicated by Arrhythmia. International Journal of Laboratory Medicine, 40(20): 2534–2537.
Wang G, Li Y, Zhang J, et al., 2018, Clinical Effect of Metoprolol Combined with Amiodarone on Coronary Heart Disease Patients with Arrhythmia. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 7(8): 42–43.
Zhou X, Zou J, Luo X, et al., 2019, Study on the Incidence of Reperfusion Arrhythmia in Patients with Acute Myocardial Infarction After PCI Treatment and its Correlation with Clinical Characteristics. Journal of PLA Medicine, 31(08): 39–43.
Ala T, Yu B, Wang Z, 2019, Effect of Combined Treatment of Wenxin Granules and Metoprolol Succinate Sustained-Release Tablets on HRV Indicators in Patients with Coronary Heart Disease and Arrhythmia. Chinese Practical Medicine, 14(20): 90–91.
Zhu S, 2019, Amiodarone Combined with Metoprolol Succinate in the Treatment of Ventricular Arrhythmias. China Health Standard Management, 10(15): 32–33.
Yang H, 2019, Analysis of The Efficacy and Incidence of Adverse Reactions in Treating Hypertrophic Cardiomyopathy with Malignant Ventricular Arrhythmias Combined with Low-Dose Amiodarone and Betaloc. Chinese Medical Guidelines, 17(16): 125–126.
Cheng C, 2018, Effect of Amiodarone Combined with Metoprolol on Ventricular Arrhythmia. Doctor, 4(8): 18–19.
Luo Q, Wang F, Liu J, et al., 2018, Effect of Amiodarone Combined with Psychological Intervention in Treating Arrhythmia and its Effect on Serum High-Sensitivity C-Reactive Protein. Bethune Medical Journal, 16(04): 395–397.