Keywords
Lupus nephritis
Class V lupus nephritis
Submitted : 2023-10-28
Accepted : 2023-11-12
Published : 2023-11-27
Abstract
Membranous lupus nephritis (MLN), class V, is a distinct LN characterized by immune complex deposition on subepithelial kidney biopsy. MLN is often associated with nephrotic syndrome. The histology of MLN is very similar to idiopathic (primary) membranous nephropathy (pMN). However, MLN usually has abundant mesa-glomerular deposits absent in primary membranous nephropathy. The clinical manifestations, management, and prognosis of MLN differ from other types of LN (type III, IV, or mixed type III/IV + V). Although immunosuppressive therapy is often necessary for MLN, the optimal treatment regimen is yet to be determined. This review summarizes the progress in the diagnosis and treatment of MLN and discusses the selection of immunosuppressants for MLN.
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