Keywords
Depression
Cognitive impairment
Submitted : 2023-08-23
Accepted : 2023-09-07
Published : 2023-09-22
Abstract
Objective: To explore the clinical characteristics and analyze the influencing factors of depression and cognitive
impairment in Parkinson’s patients. Methods: 127 patients with Parkinson’s disease who were treated in two hospitals from March 2021 to March 2023 were selected for this study. The assessment of depression was conducted using the Geriatric Depression Self-Rating Scale (GDS). In addition, cognitive function was evaluated through the Montreal Cognitive Assessment (MOCA), and the clinical attributes of patients with cognitive impairment were examined. The study also aimed to analyze the factors that influence cognitive impairment in this patient population. Results: The progression of the disease, presence of cognitive impairment, and the Hoehn-Yahr stage were identified as significant influencing factors for depression among the 127 patients with Parkinson’s disease (P < 0.05). The factors that influence cognitive impairment included the level of education, Hoehn-Yahr stage, and depression (P < 0.05). Conclusion: Depression and cognitive dysfunction is relatively common in patients with Parkinson’s disease. The occurrence of depression and cognitive dysfunction varies significantly based on factors such as the duration of the disease, varying drug dosages, and the severity of the condition. Therefore, it is necessary to treat patients with Parkinson’s disease.
References
Cai Z, Tang C, Zeng M, 2023, Analysis of Clinical Characteristics and Influencing Factors of Depression and Cognitive Dysfunction in Parkinson’s Patients. Practical Hospital Clinical Journal, 20(03): 125–129.
Zeng M, Li M, Chen J, et al., 2022, Analysis of Clinical Characteristics and Related Factors of Depression and Cognitive Dysfunction in Parkinson’s Patients. Hebei Medicine, 28(03): 465–472.
Shen G, Ding X, Jiang J, et al., 2021, The effect of Memantine on Depressive Patients with Parkinson’s Disease and Cognitive Impairment. Modern Practical Medicine, 33(08): 1094–1096.
Li X, Liu J, Li X, et al., 2019, Effects of Mild Cognitive Impairment, Anxiety and Depression on the Quality of Life of Patients with Parkinson’s Disease. Chinese Clinical Neuroscience, 27(06): 687–689.
Wang J, 2017, Clinical Analysis of Depression and Cognitive Impairment in Patients with Parkinson’s Disease. Electronic Journal of Clinical Medicine Literature, 4(91): 17848–17849.
Shi S, 2016, The Influence of Anxiety, Depression and Cognitive Function on the Motor Function of Patients with Parkinson’s Disease, dissertation, North China University of Science and Technology.
Chen J, 2015, Research on Cognition, Sleep and Depression in Patients with Essential Tremor and Parkinson’s Disease, dissertation, Soochow University.
Zhang Y, 2014, Research on Autonomic Dysfunction in Patients with Parkinson’s Disease, dissertation, Hebei Medical University.
Wang J, Cui X, Zhou C, et al., 2013, Research Progress in Clinical Application of Cognitive Behavioral Therapy. Chinese Rehabilitation Theory and Practice, 19(09): 834–838.
Zhu W, Wang J, Zhu L, et al., 2016, Changes in Serum Levels of Serotonin, Adrenaline and Inflammatory Factors in Patients with Parkinson’s Disease Complicated with Depression and Their Relationship with Cognitive Dysfunction. International Journal of Psychiatry, 43(06): 981–984 + 988.
Liu H, Li D, Qiu F, et al., 2016, Effects of Emotions on Cognitive Function in Patients with Mild to Moderate Parkinson’s disease. Chinese Journal of Modern Nervous Diseases, 16(02): 92–97.
Wang H, Jiang T, 2015, Discussion on the Relationship Between Blood Uric Acid and Cognitive Dysfunction in Elderly Patients with Parkinson’s Disease. Clinical Medical Engineering, 22(08): 1064–1066.
Li D, 2015, Clinical Observation of Venlafaxine Improving Depression and Cognitive Function in Patients with Parkinson’s Disease. Journal of Henan Medical College, 27(03): 287–288.
Nie L, 2015, Clinical Efficacy of Venlafaxine Combined with Cognitive Behavioral Intervention in the Treatment of Parkinson’s Disease Complicated with Depression and Cognitive Dysfunction. Chinese Medical Science, 5(06): 165–167 + 170.
Dong J, 2015, New Progress in Research on the Correlation Between Depression and Cognitive Dysfunction in Patients with Parkinson’s Disease. Chinese Medicine Guide, 13(07): 80–81.