Keywords
Supramolecular salicylic acid
Domain hair spray dressing
Submitted : 2023-02-27
Accepted : 2023-03-14
Published : 2023-03-29
Abstract
Objective: To observe the clinical efficacy of 30% supramolecular salicylic acid combined with Yufa spray dressing in the treatment of moderate to severe seborrheic dermatitis (seborrheic dermatitis of the scalp, SDS). Methods: From January 2020 to December 2021, 150 patients with SDS, who were treated in the Dermatology Clinic of the First Affiliated Hospital of Xi’an Medical University, were randomly divided into two groups, a treatment group and a control group, with 75 cases in each group. The treatment group was given 30% supramolecular salicylic acid combined with Yufa spray dressing on the basis of external medicine given to the control group, while the control group was given oral medicine combined with external medicine. Results: The difference in scores of erythema, scales, pruritus, and folliculitis of the treatment group before and after treatment was significant (P < 0.01), indicating that supramolecular salicylic acid combined with Yufa spray dressing can relieve the symptoms of SDS. The difference in scores of erythema of the control group before and after treatment was significant as well (P < 0.05), indicating that traditional antibiotics are also effective in treating SDS; however, there was no significant difference (P > 0.05) in the scores of other signs and symptoms, such as scales, pruritus, and folliculitis, before and after treatment, indicating that traditional antibiotics have no obvious curative effect on SDS. After 12 weeks of treatment, the improvement in erythema, scaling, and folliculitis was significantly greater in the treatment group compared with the control group (P < 0.05). Curative effect comparison showed that the total effective rate of the treatment group was 80.00%, compared with 25.67% of the control group, and the difference was statistically significant (P < 0.05). Conclusion: 30% supramolecular salicylic acid combined with Yufa spray dressing can significantly improve the therapeutic effect in moderate to severe SDS; the recurrence rate is lower, the course of treatment is shorted, and patients generally feel better; thus, it is a new option for the treatment of dermatitis.
References
Tang L, Zhou X, Wang S, 2021, An Overview of the Etiology and Treatment of Seborrheic Dermatitis of the Scalp. Journal of Practical Chinese Medicine, 37(06): 1074–1076.
Elgash M, Dlova N, Ogunleye T, et al., 2019, Seborrheic Dermatitis in Skin of Color: Clinical Considerations. Journal of Drugs in Dermatology, 18(1): 24–27.
Suchonwanit P, Triyangkulsri K, Ploydaeng M, et al., 2019, Assessing Biophysical and Physiological Profiles of Scalp Seborrheic Dermatitis in the Thai Population. BioMed Research International, 2019: 5128376.
Adalsteinsson JA, Kaushik S, Muzumdar S, et al., 2020, An Update on the Microbiology, Immunology and Genetics of Seborrheic Dermatitis. Experimental Dermatology, 29(5): 481–489.
Singh K, Camera E, Krug L, et al., 2018, JunB Defines Functional and Structural Integrity of the Epidermo-Pilosebaceous Unit in the Skin. Nature Communications, 9(1): 3425.
Sun J, Lin C, Wang Y, et al., 2021, A Case of AIDS with Seborrheic Dermatitis as the First Manifestation. Chinese Journal of Leprosy and Skin Diseases, 37(07): 460–462.
Li S, Liu Y, Zhang C, et al., 2012, Observation on the Curative Effect of Pyrithione Zinc Aerosol in the Treatment of 48 Cases of Scalp Seborrheic Dermatitis. Chinese Journal of Leprosy and Skin Diseases, 28(08): 603–604.
Fu R, Li Y, 2015, External Drug Treatment of Scalp Seborrheic Dermatitis. Chinese Journal of Integrated Traditional Chinese and Western Medicine Dermatology, 14(04): 270–272.
Zou F, Li Y, Min H, et al., 2015, Clinical Efficacy Analysis of Itraconazole Combined with 2% Ketoconazole in the Treatment of Scalp Seborrheic Dermatitis. Chinese Medicine Guide, 13(07): 36–37.
Jiang H, 2021, Observation of Curative Effect of Yufa Spray Dressing on Mild to Moderate Scalp Seborrheic Dermatitis, thesis, Jilin University.
Yan Y, 2011, Treatment of Dry Seborrheic Dermatitis with Traditional Chinese Medicine Taken Orally and Washed Externally. Chinese Folk Therapy, 19(08): 50–51.
Wang R, 2006, Establishment and Application Research of Anti-Dandruff Cosmetics Efficacy Evaluation Method, thesis, Jilin University.
Yang L, Lin X, Luo X, et al., 2021, Efficacy Evaluation of 30% Supramolecular Salicylic Acid Combined with Antibacterial Gel in the Treatment of Mild to Moderate Acne Vulgaris. Chinese Aesthetic Medicine, 30(06): 64–68.
Hu X, Cheng Q, Yuan J, et al., 2021, Clinical Efficacy of Salicylic Acid Anti-Dandruff Hair Care Lotion in the Treatment of Scalp Seborrheic Dermatitis. Disease Surveillance and Control, 15(04): 258–261.
Li W, Lv W, 2022, Clinical Observation of Traditional Chinese Medicine Combined with Ketoconazole in the Treatment of Scalp Seborrheic Dermatitis. Journal of Practical Chinese Medicine, 38(12): 2106–2107.
Li T, Zou D, Zhang L, et al., 2019, Advances in TCM External Treatment of Scalp Seborrheic Dermatitis. Yunnan Journal of Traditional Chinese Medicine, 40(02): 81–83.
Gao R, 2021, Experimental Study on Antibacterial Activity of Yufa Spray Dressing Against Malassezia In Vitro, thesis, Jilin University. https://doi.org/10.27162/d.cnki.gjlin.2021.003452
Huang X, Li Y, Qi N, et al., 2020, Biological Activity of Antimicrobial Peptides and Their Role in Livestock and Poultry Production. Advances in Veterinary Medicine, 41(12): 115–119.
Li Y, Yao Q, Ren M, et al., 2019, Research Progress on the Mechanism of Action of Antimicrobial Peptides. Advances in Veterinary Medicine, 40(09): 98–103.
Ganz T, Lehrer RI, 1999, Antibiotic Peptides from Higher Eukaryotes: Biology and Applications. Mol Med Today, 5(7): 292–297.