Keywords
Articular cartilage
Icariin
Cartilage cells
Submitted : 2022-04-30
Accepted : 2022-05-15
Published : 2022-05-30
Abstract
Osteoarthritis (OA) is a multifaceted bone and joint disease with degenerative changes of articular cartilage. Therefore, the current research on the etiology of OA mainly focuses on the etiology of articular cartilage degeneration. Clarifying the pathogenesis of OA from the molecular level has become an important research topic in the field of orthopedics. Its main pathological features are the decrease of chondrocyte metabolic activity, cartilage matrix degradation, and osteophyte formation. Icariin (ICA) is the main active monomer of epimedium, a traditional Chinese medicine, and the pharmacological research has revealed favorable effects of ICA on the bone system. ICA can promote the proliferation of chondrocytes and inhibit the apoptosis of chondrocytes, alleviate the degradation rate of cartilage matrix, and effectively protect articular cartilage. This review also expounds the mechanism of promoting cartilage repair.
References
Bertrand J, Cromme C, Umlauf D, et al., 2010, Molecular Mechanisms of Cartilage Remodelling in Osteoarthritis. Int J Biochem Cell Biol, 42(10): 1594-1601.
Charlier E, Deroyer C, Ciregia F, et al., 2019, Chondrocyte Dedifferentiation and Osteoarthritis (OA). Biochem Pharmacol, 165: 49-65.
Li C, Zhao P, Qin Y, et al., 2020, Research Progress on Pharmacological Activity of Icariin. Journal of Traditional Chinese Medicine, 35(4): 781-786.
Zu Y, Mu Y, Li Q, et al., 2019, Icariin Alleviates Osteoarthritis by Inhibiting NLRP3-Mediated Pyroptosis. J Orthop Surg Res, 14(1): 307.
Singh P, Marcu KB, Goldring MB, et al., 2019, Phenotypic Instability of Chondrocytes in Osteoarthritis: On a Path to Hypertrophy. Ann N Y Acad Sci, 1442(1): 17-34.
Wang P, Meng Q, Wang W, et al., 2020, Icariin Inhibits the Inflammation Through Down-Regulating NF-?B/HIF-2? Signal Pathways in Chondrocytes. Biosci Rep, 40(11): BSR20203107. DOI: 10.1042/BSR20203107
Zhao X, 2018, Effect of Icariin on Proliferation and Apoptosis of Chondrocytes in Human Osteoarthritis. Hainan Medical Journal, 29(01): 10-13.
Choi MC, Jo J, Park J, et al., 2019, NF-?B Signaling Pathways in Osteoarthritic Cartilage Destruction. Cells, 8(7): 734.
Zeng J, Ke J, 2020, Role of Subchondral Bone Lesions in the Pathogenesis of Osteoarthritis. Chinese Journal of Cell Biology, 42(07): 1255-1262.
Jiang T, Ling C, Chen Q, et al., 2021, Icariin Promotes Osteoblast Differentiation and Prevention of Osteoporosis by Enhancing Autophagy. China Engineering Research, 25(17): 2643-2649.
Wang W, Kong B, Tang C, et al., 2019, Progress in the Treatment of Osteoarthritis with Mesenchymal Stem Cells. Journal of Henan Normal University (Natural Science Edition), 47(6): 82-88, 2.
Zhang Q, Yang T, Lou J, 2020, Research Progress of Bone Marrow Mesenchymal Stem Cells Proliferation and Differentiation Induced by Kidney-Tonifying Chinese Herbs in Prevention and Treatment of Osteoporosis. Chinese Journal of Traditional Chinese Medicine, 38(03): 193-195.
Wei Q, He M, Chen M, et al., 2017, Icariin Stimulates Osteogenic Differentiation of Rat Bone Marrow Stromal Stem Cells by Increasing TAZ Expression. Biomed Pharmacother, 91: 581-589.
Li L, Zheng H, Kou Y, et al., 2018, Study on the Differentiation of Bone Marrow Mesenchymal Stem Cells Induced by Icariin. China Journal of Traditional Chinese Medicine and Pharmacy, 33(6): 2599-2601.
Theocharis AD, Skandalis SS, Gialeli C, et al., 2016, Extracellular Matrix Structure. Adv Drug Deliv Rev, 97: 4-27.
Karamanos NK, Theocharis AD, Piperigkou Z, et al., 2021, A Guide to the Composition and Functions of the Extracellular Matrix. FEBS J, 288(24): 6850-6912.
Wu S, Wu C, Guo X, 2021, Degradation Difference of Cartilage Extracellular Matrix between Kashin Beck Disease and Osteoarthritis. Journal of Xi’an Jiaotong University (Medical Edition), 42(2): 306-310, 316.
Zeng L, Rong XF, Li RH, et al., 2017, Icariin Inhibits MMP1, MMP3 and MMP13 Expression Through MAPK Pathways in IL1?-Stimulated SW1353 Chondrosarcoma Cells. Mol Med Rep, 15(5): 2853-2858.