Keywords
Guizhi
Gout
Network pharmacology
Target
Signal pathway
Submitted : 2025-02-08
Accepted : 2025-02-23
Published : 2025-03-10
Abstract
Objective: To explore the mechanism of action of “Weilingxian-Guizhi” two drugs in the treatment of gout. Method: First obtain the 15 chemical components contained in the “Weilingxian-Guizhi” drug, predict its target points through the database, and then construct the gout-related protein-protein interaction network (PPI), and then construct the “Weiling,” the “Xian, Guizhi” drug pair “active ingredient-predicted target” network, the construction of the gout-related “Weilingxian-Guizhi” drug pair “active ingredient-potential target” network, based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway enrichment analysis and gene ontology (GO) functional enrichment analysis, to study the mechanism of action of the two drugs “Weilingxian-Guizhi” in the treatment of gout. Results: The gout-related “Weilingxian-Guizhi” drug pair “active ingredient-potential target” network contains 14 targets. KEGG pathway enrichment analysis yields 32 pathways, and GO functional enrichment analysis yields 517 GO entries. Among them, there are 468 items related to biological processes, 21 items related to molecular functions, and 28 items related to cell composition. Conclusion: The results of this study initially verified and predicted the mechanism of the “Weilingxian-Cinnamon Stick” medicine on the treatment of gout, and laid a good foundation for further revealing its mechanism of action.
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