Keywords
Pyroptosis
Macrophages
Submitted : 2025-02-08
Accepted : 2025-02-23
Published : 2025-03-10
Abstract
Pyroptosis is a form of programmed cell death. Excessive or uncontrolled pyroptosis and the production of pro-inflammatory cytokines can lead to organ damage, circulatory failure, and even death. Gasdermin D (GSDMD) is the primary executor of pyroptosis in macrophages. Upon cleavage, the N-terminal domain of GSDMD (GSDMD-N) is activated and oligomerizes to form pore-like structures in the plasma membrane, triggering pyroptosis and resulting in the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β). As a key executioner molecule of pyroptosis, Gasdermin D plays a crucial role in pathogen-induced pyroptosis in macrophages. With in-depth research on the function and regulatory mechanisms of GSDMD, its role in pathogen-induced macrophage pyroptosis has gradually been revealed. This article elaborates on the mechanism of GSDMD in pathogen-induced macrophage pyroptosis, providing insights for exploring pyroptosis in the prevention and control of bacterial diseases, and identifying new therapeutic targets for bacterial infections.
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