Keywords
Blood lipids
Blood glucose
Liver function
Submitted : 2025-02-08
Accepted : 2025-02-23
Published : 2025-03-10
Abstract
Objective: To study the clinical value of combined detection of blood lipids, blood glucose, and liver function in non-alcoholic fatty liver disease. Methods: 105 patients with non-alcoholic fatty liver disease treated in our hospital from May 2022 to July 2024 were selected as the research subjects. All patients underwent a B-ultrasound examination. According to the severity of the disease, they were divided into group A (mild, n = 35), group B (moderate, n = 44), and group C (severe, n = 26). Another 30 healthy residents who came to the hospital for physical examination during the same period were selected as group D. The differences in blood lipids, blood glucose, and liver function indicators between groups were compared. Results: The triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) levels in groups A, B, and C were higher than those in group D, while the high-density lipoprotein cholesterol (HDL) level was lower (P < 0.05). The fasting plasma glucose (FPG) levels in groups B and C were higher than those in group D (P < 0.05). The TG, LDL, and FPG levels in groups B and C were higher than those in group A (P < 0.05). The TC level in group C was higher than that in group A, while the HDL level was lower (P < 0.05). The TC and FPG levels in group C were higher than those in group B (P < 0.05). The total bilirubin (TBil), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in groups A, B, and C were higher than those in group D (P < 0.05). The TBil and ALT levels in groups B and C were higher than those in group A (P < 0.05). The AST level in group C was higher than that in group A (P < 0.05). The AST and ALT levels in group C were higher than those in group B (P < 0.05). Conclusion: Patients with non-alcoholic fatty liver disease have disordered glucose and lipid metabolism. Blood lipids, blood glucose, and liver function are closely related to the severity of the disease. Strengthening exercise and dietary intervention early on can help control the progression of simple fatty liver disease and reduce the risk of severe liver diseases such as steatohepatitis and cirrhosis.
References
Xiong L, Wang S, Xiang Q, et al., 2021, Application Value of Liver Transient Elastography and Ultrasonic Diagnostic Parameters in the Diagnosis and Severity Evaluation of Fatty Liver. Journal of Molecular Imaging, 44(5): 820–823.
Zhang X, Guo R, Zhang Y, et al., 2023, Study on the Improvement of Glucose and Lipid Metabolism Indexes, Liver Function, and Inflammatory Factors by Probiotics Combined with Silibinin in Elderly Patients with Nonalcoholic Fatty Liver Disease. Journal of Clinical Military Medical Sciences, 51(2): 206–209.
Wang L, Lin X, Ding N, 2022, Comparison of Serum Lipidomics Between Patients with Nonalcoholic Simple Fatty Liver and Nonalcoholic Steatohepatitis. Journal of Practical Hepatology, 25(2): 215–218.
Shi A, Wang Y, Ma W, et al., 2023, Analysis of Liver Biochemical Indicators and Metabolism-Related Factors in Non-Uniform Fatty Liver. Liver, 28(11): 1346–1350.
Feng J, Pan Q, 2021, Diagnostic Efficacy of Serum Total Bile Acid and Blood Lipids for Liver Fibrosis in Chronic Hepatitis B. Journal of Integrated Traditional Chinese and Western Medicine on Liver Diseases, 31(10): 930–932.
Fatty Liver and Alcoholic Liver Disease Group, Chinese Medical Association Liver Diseases Branch, 2003, Diagnostic Criteria for Nonalcoholic Fatty Liver Disease. Chinese Journal of Hepatology, 11(2): 71–71.
Chu Y, Wang D, Lu Z, 2022, Effects of Dapagliflozin Combined with Liraglutide on Inflammatory Factors, Glucose and Lipid Metabolism, and Liver Function in Patients with Type 2 Diabetes Mellitus Complicated with Nonalcoholic Fatty Liver Disease. Evaluation and Analysis of Drug Use in Chinese Hospitals, 22(9): 1064–1067 + 1071.
Li C, Guo S, Li Y, et al., 2024, Analysis of the Incidence and Influencing Factors of Nonalcoholic Fatty Liver Disease Among Rural Uyghur Residents in Xinjiang Production and Construction Corps. Chinese Journal of Epidemiology, 45(8): 1149–1157.
Gao M, Zhao B, Zhou L, 2021, Effects of Intestinal Flora Regulation Therapy on Liver Function and Blood Lipid Metabolism in Patients with Nonalcoholic Fatty Liver Disease. Journal of North Sichuan Medical College, 36(12): 1597–1599 + 1608.
Guo X, Han M, Ma D, et al., 2024, Study on the Relationship Between Nonalcoholic Fatty Liver Disease, Liver Fibrosis, and Skeletal Muscle Mass in Patients with Type 2 Diabetes Mellitus. Chinese Journal of Endocrinology and Metabolism, 40(8): 660–668.
Liu C, Ma L, Liu F, et al., 2024, Predictive Value and Influencing Factors Analysis of Serum AMPK-α mRNA and Caspase-6 mRNA Levels on the Efficacy of Nonalcoholic Fatty Liver Disease. Journal of Xinjiang Medical University, 47(7): 1001–1007.
Wang Y, Zhao Q, Chen B, et al., 2023, Association Analysis Between Metabolic-Related Chronic Disease Combinations and Nonalcoholic Fatty Liver Disease Among Community Residents in Shanghai. Chinese Journal of Epidemiology, 44(7): 1106–1113.
Ouyang D, Xu D, Sun Y, et al., 2024, Construction of a Prediction Model for Nonalcoholic Fatty Liver Disease in Non-Obese Populations Based on Lifestyle-Related Indicators. Journal of Nursing, 31(10): 1–7.
Yan W, Guo D, Sun X, 2023, Analysis of Changes in Serum Small Dense Low-Density Lipoprotein and Its Relationship With Insulin Resistance and Fat Attenuation Index in Patients With Type 2 Diabetes Mellitus Complicated With Nonalcoholic Fatty Liver Disease. Hebei Medical Journal, 29(11): 1868–1872.
Peng Y, Zhu H, Yang M, et al., 2022, Effects of 12-Week FATmax Intensity Exercise on Blood Glucose, Lipids, and Liver Function in Patients With Obese Nonalcoholic Fatty Liver Disease. Genomics and Applied Biology, 41(3): 648–658.
Hao L, Wang M, Qiao T, 2024, Correlation Analysis Between Nutritional Status and Liver Function, Inflammatory Factors, and Prognosis in Patients With Liver Cancer. Electronic Journal of Cancer Metabolism and Nutrition, 11(1): 96–101.
Lin X, Wu W, Xun Z, 2024, Correlation Analysis Between Platelet-Albumin-Bilirubin Score and Child-Turcotte-Pugh Classification of Liver Function in Patients With Liver Cirrhosis. Journal of Fujian Medical University, 58(1): 37–43.
Shang N, Huang X, Ye Y, et al., 2023, Correlation Study Between Liver Stiffness Measurement, AST/ALT Ratio, and Staging of Primary Biliary Cholangitis. Journal of Integrated Traditional and Western Medicine on Liver Diseases, 33(5): 418–420.
Lv Y, Jiang S, Lv J, et al., 2022, Correlation Analysis Between the Degree of Esophageal Varices in Liver Cirrhosis and Laboratory Test Indicators. Liver, 27(10): 1096–1101.
Jiang C, Wang J, Li Y, et al., 2024, Study on the Effect of Aerobic Exercise on the Improvement of Nonalcoholic Fatty Liver Disease by Regulating the NF-κB Signaling Pathway Through CNPY2. Modern Preventive Medicine, 51(11): 2100–2107.