Keywords
Grain-sized moxibustion
Diarrhea-predominant irritable bowel syndrome
Liver depression and spleen deficiency syndrome
Submitted : 2025-02-05
Accepted : 2025-02-20
Published : 2025-03-07
Abstract
Objective: To evaluate the therapeutic effect of Shu Gan Jian Pi Yi Qi prescription combined with grain-sized moxibustion on diarrhea-predominant irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency syndrome. Methods: 60 patients with IBS-D (liver depression and spleen deficiency syndrome) treated in the outpatient clinic from January 2021 to December 2023 were selected and randomly divided into two groups using a random number table. The combined group was treated with Shu Gan Jian Pi Yi Qi prescription and grain-sized moxibustion, while the reference group was treated with western medication. The total effective rate, IBS symptom severity score (IBS-SSS), Bristol stool scale score, and IBS-specific quality of life questionnaire (IBSQOL) were compared between the two groups. Results: The total effective rate of the combined group was higher than that of the reference group (P < 0.05). Before treatment, there were no differences in IBS-SSS score, Bristol stool scale score, and IBSQOL score between the two groups (P > 0.05). After treatment, the IBS-SSS score and Bristol stool scale score of the combined group were lower than those of the reference group, while the IBSQOL score was higher (P < 0.05). Conclusion: Shu Gan Jian Pi Yi Qi prescription combined with grain-sized moxibustion can improve the symptoms of IBS-D patients, including stool characteristics, and enhance their quality of life.
References
Lai B, Hong M, Li X, et al., 2024, Preparation of a Rat Model of Diarrhea-Predominant Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Induced by Acetic Acid Enema Combined with Restraint and Tail-Clamp Stress. Chinese Journal of Laboratory Animal Science, 32(3): 317–328.
Xiao X, Hu L, Chen J, et al., 2023, Observation on the Efficacy of Heat-Sensitive Grain-Sized Moxibustion in Treating Irritable Bowel Syndrome. Journal of External Therapy of Traditional Chinese Medicine, 32(6): 52–55.
Chen Q, Bao K, Du X, 2020, Observation on the Efficacy of Grain-Sized Moxibustion Combined with Yimu Decoction in Treating Irritable Bowel Syndrome and Its Impact on Mental Health. Chinese Journal of Traditional Medical Science and Technology, 27(5): 804–805.
Gao W, Yu J, Hua J, 2021, Clinical Study on Self-Prescribed Yiqi Shugan Jianpi Decoction in Treating Nonalcoholic Fatty Liver Disease. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 31(3): 209–212.
Liu F, Liu G, 2021, Clinical Observation on Yiqi Shugan Jianpi Decoction Combined with Polyenylphosphatidylcholine in Treating Nonalcoholic Fatty Liver Disease. Chinese Journal of Modern Distance Education of Traditional Chinese Medicine, 19(13): 131–133.
Lin X, Deng N, Xia X, et al., 2024, Effects of Sishen Pills on the Expression of MCT and c-Fos in the Colon of Rats with Diarrhea-Predominant Irritable Bowel Syndrome. Chinese Traditional Patent Medicine, 46(5): 1658–1661.
Wang K, Yang Q, 2021, Observation on the Efficacy of Shugan Zhonghe Decoction in Treating Diarrhea-Predominant Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency. Journal of Clinical Medicine in Practice, 25(23): 58–61 + 68.
Wu Y, 2024, Clinical Observation on the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Using Shugan Jianpi Yiqi Formula Combined with Grain-Sized Moxibustion. Chinese Journal of Modern Distance Education of Traditional Chinese Medicine, 22(18): 100–103.
Zhuang Y, Huang S, Li H, 2023, Observation on the Efficacy of Wrist-Ankle Acupuncture Combined with Jianpi Shugan Formula in Treating Patients with Irritable Bowel Syndrome of Spleen Deficiency and Qi Stagnation Type. World Journal of Integrated Traditional and Western Medicine, 18(12): 2498–2502.
Wu B, Wang X, Fu D, et al., 2022, Efficacy of Shugan Jieyu Formula on a Rat Model of Constipation-Predominant Irritable Bowel Syndrome and Its Effects on Brain-Gut Axis Function. Laboratory Animal and Comparative Medicine, 42(6): 551–559.