Keywords
Postoperative cognitive dysfunction
Effects
Submitted : 2025-02-05
Accepted : 2025-02-20
Published : 2025-03-07
Abstract
Postoperative cognitive dysfunction is a typical complication, which can be referred to as POCD. This complication is common in elderly patients. Among them, POCD is mainly manifested in the function of patients with attention deficit and memory reduction after surgery, among which serious patients are prone to personality change, which affects their social behavior ability. In the context of the current era, the cause of POCD is not clear, combined with the results of most studies, it is found that central nervous inflammation, is a key factor affecting POCD. From the perspective of central inflammation, this paper analyzes the relationship between central inflammation and POCD, and discusses the mechanism of action, aiming at effectively preventing and treating POCD and providing a reference for subsequent research in related fields.
References
Zhang Q, 2024, Study on the Relationship Between Serum SOD Activity and Cognitive Dysfunction in Elderly Patients After CABG Operation, thesis, Chengde Medical College.
Li H, Tao L, 2019, Research Progress on the Inflammatory Etiology of Postoperative Cognitive Dysfunction. Journal of Modern Medicine and Health Research, 7(18): 130–133.
Hou L, He Y, Ma J, et al., 2019, Effects of Polydatin on Postoperative Cognitive Dysfunction, Hippocampal Oxidative Stress, and Neuroinflammation in Aged Mice. Advances in Modern Biomedicine, 23(13): 2429–2433.
Li Y, 2023, Clinical Effect of Shenfu Injection on Postoperative Cognitive Dysfunction in Elderly Patients With Hip Fracture Under Intraspinal Anesthesia, thesis, Shandong University of Chinese Medicine.
Zhou C, 2023, The Effect of Esketamine on Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Thoracoscopic Surgery, thesis, Nanjing Medical University.
Xiang J, Wang J, Li X, et al., 2022, Demedetomidine Regulates NLRP3 Inflammasome Activation and Improves Cognitive Dysfunction in Animal Model After Operation. Journal of Hebei Medicine, 44(13): 1934–1938.
Liu Y, Zhang LY, Zhang DD, et al., 2019, Research Progress of Inflammatory Mechanisms and Related Biomarkers in Postoperative Cognitive Dysfunction. Contemporary Medicine, 28(19): 191–194.
Cheng S, Deng L, Ji F, 2022, Postoperative Cognitive Dysfunction and the Research Progress of Inflammation of the Central Nervous System. Jiangsu Medicine, 13(6): 633–637.
Wu X, 2022, Molecular Mechanism of β-Amyloid Protein and the "Vicious Cycle" of Neuroinflammation Involved in the Pathogenesis of Postoperative Cognitive Dysfunction. The Affiliated Hospital of Ningbo University School of Medicine, Zhejiang Province, 2022-06-10.
Wang Y, Peng S, Zhu J, et al., 2019, The Effect of Agmatine on Postoperative Central Inflammatory Response and Cognitive Dysfunction in Rats. Journal of Xuzhou Medical University, 42(5): 336–342.
Yang P, 2021, Study on the Mechanism of Neuronal Inflammation in Postoperative Cognitive Dysfunction in Aged Mice. The First Affiliated Hospital of Chengdu Medical College, Sichuan Province, 2021-04-13.
Wen G, 2021, Study on the Mechanism of Abnormal Phosphorylation of Tau Protein and Neuroinflammation in the Occurrence of Acute Stage Cognitive Dysfunction After Caesarean Section in Mice, thesis, Anhui Medical University
Shi L, Gong T, Zhu ZQ, 2019, Research Progress on the Role of Neuroinflammation in Postoperative Cognitive Dysfunction. Guizhou Med, 44(9): 1364–1365.
Li G, Fan D, 2019, Research Progress of the Mechanism Related to Postoperative Cognitive Dysfunction and Central Nervous Inflammation. Clinical Journal of Practical Hospital, 17(1): 195–198.
Wei Q, Xie M, 2019, Anesthesia and Postoperative Cognitive Dysfunction in Elderly Patients With Study. World's Latest Medical Information Abstract, 12(75): 31 + 35.