Keywords
Anticancer drugs
Synergy
Enhancement mechanisms
Submitted : 2025-01-15
Accepted : 2025-01-30
Published : 2025-02-14
Abstract
With the continuous advancement of cancer treatment methods, plasma combined with drug therapy has garnered widespread attention as an emerging therapeutic strategy. This paper elaborates on the generation and characteristics of plasma, as well as its mechanisms of action on cancer cells when used alone, including the production of reactive oxygen and nitrogen species, and damage to cancer cell membranes, and organelles. It emphasizes the synergistic mechanisms observed when plasma is combined with various anticancer drugs (e.g., chemotherapeutic agents, targeted drugs, and immunotherapies). The analysis focuses on enhancing drug uptake, promoting the activation of drug action targets, and improving the tumor microenvironment. These insights provide a theoretical basis for optimizing plasma-drug combination therapy for cancer.
References
Zhang J, 2021, Research Progress on the Application of Plasma Technology in the Field of Materials. Safety, Health and Environment, 21(1): 1–7.
Gao X, 2022, Application of Plasma Integrated Equipment in Medical Wastewater Treatment. Yunnan Chemical Industry, 49(8): 104–106.
Li X, Zhao H, Zhang M, et al., 2020, Research on Plasma Treatment Technology for Medical Waste. Chemical Management, 2020(31): 63–64.
Wang M, 2019, Research on the Treatment of Typical Components of Medical Waste Using Carbon Dioxide Thermal Plasma Technology, dissertation, Zhejiang University.
Hao S, 2018, Techno-Economic Analysis of Plasma Treatment for Medical Waste. Applied Chemical Industry, 47(10): 2192–2196.
Lu D, Zhuang J, Dong Z, 2008, Discussion on the Application of Low-Temperature Hydrogen Peroxide Plasma Sterilization Technology in the Medical Field. Medical Equipment, 2008(3): 15–16.
Dong J, 2004, Low-Energy Plasma Medical Waste Incineration Technology and Equipment. Henan Province. Kaifeng City Deyi Environmental Protection Equipment Industrial Co., Ltd., 2004-01-01.
Zong W, 2011, Application of Plasma Technology in Biomedical Materials (Review). Proceedings of the 31st Annual Conference of Tianjin Biomedical Engineering Society, 2011: 1.
Wei Y, 2012, Plasma Surface Modification of Biomedical Materials and Its Performance Research, dissertation, Shaanxi Normal University.
Pang J, Lin Z, Zhang Z, et al., 2015, Research on Hydrophilic Surface Preparation of Medical Titanium Materials Based on Plasma Oxidation Technology. Vacuum, 52(2): 70–74.