Keywords
Blood-brain barrier
Liposome
Gold nanoparticles
Drug delivery
Submitted : 2024-12-03
Accepted : 2024-12-18
Published : 2025-01-02
Abstract
Delivering therapeutic agents to the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB). This study presents a novel approach utilizing near-infrared (NIR) light-responsive gold-coated cubic vesicles (Auslip) to modulate BBB permeability and enhance drug delivery to glioma cells. Upon NIR activation, Auslip releases encapsulated agents and transiently opens the BBB. The results demonstrate that Auslip increases doxorubicin (DOX) delivery to glioma C6 cells in a co-culture model with human brain microvascular endothelial cells (hCMEC/D3). This approach offers a promising strategy for CNS therapeutics by enabling simultaneous BBB opening and drug release through optical stimulation.
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