Keywords
Travoprost eye drops
Open-angle glaucoma
Visual acuity
Intraocular pressure
Submitted : 2024-10-29
Accepted : 2024-11-13
Published : 2024-11-28
Abstract
Objective: To analyze the therapeutic effects of carteolol hydrochloride (CAR) eye drops combined with travoprost (TRA) eye drops in the treatment of open-angle glaucoma (OAG). Methods: A total of 72 OAG patients (87 eyes) hospitalized between October 2020 and October 2023 were randomly divided into two groups. The combination group received CAR and TRA eye drops, while the control group received CAR eye drops alone. Treatment outcomes were compared in terms of total efficacy rate, visual acuity, intraocular pressure, visual function indicators, hemodynamic parameters, and ocular surface damage indicators. Results: The combination group showed a higher total efficacy rate compared to the control group. After 3 months of treatment, the combination group had better visual acuity, lower intraocular pressure, higher mean sensitivity, lower mean defect, lower resistance index, and higher end-diastolic velocity and peak systolic velocity compared to the control group (P < 0.05). Additionally, the combination group exhibited higher corneal fluorescein staining scores, shorter tear breakup time, and lower Schirmer tear test values compared to the control group (P < 0.05). Conclusion: The combination of CAR and TRA eye drops improves visual acuity, effectively reduces intraocular pressure, enhances visual function, regulates ocular hemodynamics, and mitigates ocular surface damage in OAG patients, demonstrating superior therapeutic efficacy.
References
Zhong YM, 2020, Clinical Efficacy of Travoprost Eye Drops Combined with Carteolol Hydrochloride Eye Drops in 40 Cases of Open-Angle Glaucoma. Heilongjiang Medical Journal, 33(4): 877–878.
Ye JX, 2021, Clinical Efficacy of Travoprost Eye Drops and Carteolol Hydrochloride Eye Drops in the Treatment of Open-Angle Glaucoma. World Latest Medicine Information, 21(68): 196–197 + 206.
Che W, Cao MC, 2023, Effect of Brimonidine Tartrate Eye Drops and Carteolol Hydrochloride Eye Drops in the Treatment of Primary Open-Angle Glaucoma. China Health Standard Management, 14(18): 126–130.
Li XY, 2021, Analysis of the Clinical Efficacy of Tafluprost Eye Drops Combined with Carteolol Hydrochloride Eye Drops in the Treatment of Open-Angle Glaucoma. Capital Food and Medicine, 28(12): 82–83.
Lin NN, Cui SS, 2020, Clinical Study of Compound Anisodine Injection Combined with Carteolol Hydrochloride Eye Drops in the Treatment of Open-Angle Glaucoma. Drug Evaluation Research, 43(7): 1382–1387.
Lian HD, Wan HJ, Zhang L, et al., 2024, Observation of the Effect of Travoprost Eye Drops Combined with Brimonidine Tartrate Eye Drops in the Treatment of Open-Angle Glaucoma Patients. Medical Theory and Practice, 37(13): 2250–2252.
Peng B, Ren L, Zhang QF, 2022, Clinical Study of Xiongdan Kaifang Tablets Combined with Travoprost Eye Drops in the Treatment of Primary Open-Angle Glaucoma. Modern Drugs and Clinics, 37(12): 2823–2828.
Lin QX, Zhang L, Li YH, 2023, Comparison of the Efficacy of Travoprost Eye Drops and Timolol Maleate Eye Drops in the Treatment of Primary Open-Angle Glaucoma. Clinical Rational Drug Use, 16(30): 149–152.
Han BY, Mi Q, Jia GM, et al., 2020, Observation of the Efficacy of Latanoprost, Timolol, and Travoprost in the Treatment of Primary Open-Angle Glaucoma. Hebei Medical Journal, 42(9): 1324–1327.
Jin LY, Yan GG, 2023, Effect of Fuming Tablets Combined with Travoprost on Intraocular Pressure and Ocular Surface Disease Index in Glaucoma Patients. Chinese Journal of Optometry and Vision Science, 25(5): 379–383.