Abstract
Objective: To observe the therapeutic effect of salvia miltiorrhiza phenylephrine combined with puerarin sodium on diabetic peripheral neuropathy (DPN) and the effect of serum insulin-like growth factor 1 (IGF-1), free fatty acid (FFA) and human myelin Protein (MBP). Methods: A total of 116 patients with diabetic peripheral neuropathy were randomly divided into observation group (58 cases) and control group (58 cases). The control group was treated with sodium prostaglandin sodium. The observation group was treated with Danshephenolic acid Treatment, treatment for 8 weeks. The changes of total symptom score system (TSS), vibration sensory threshold (VPT), ankle brachial index (ABI) and peripheral nerve conduction velocity (NCV), serum IGF-1, FFA and MBP were observed before and after treatment. Results: The levels of numbness, tingling, burning, paresthesia and total score were significantly decreased in both groups after treatment, VPT, ABI and NCV were improved (P < 0.05), and the above indexes (P < 0.05). The levels of serum IGF-1 were increased and the levels of FFA and MBP were lower in the two groups. The improvement of the above indexes was better than that of the control group (P < 0.05). Conclusion: Salvia miltiorrhiza polyphenate combined with puerarin sodium can significantly improve the vibration sensory threshold and ankle-brachial index, enhance the nerve conduction velocity and relieve clinical symptoms in patients with diabetic peripheral neuropathy. The mechanism may be related to the regulation of serum IGF-1,FFA, The level of MBP is relevant.