Objective: This study will analyze the clinical value of enteral nutrition treatment in patients with severe craniocerebral injury and discuss the safety of this treatment. Methods: This study selected patients who were treated in the hospital from January 2017 to December 2018. After the screening, all patients were diagnosed as severe craniocerebral injury. Forty-four patients who have met the experimental criteria were undergone enteral nutrition treatment to improve the condition. The success rate of catheterization and the changes in patient’s vital signs were analyzed. Especially the effect on the disease after the insertion of nasogastric tubing for nutritional treatment. Results: From the treatment results, the success rate of catheterization was 95.45% (42/44). In term of the timeline, the average was (36.5±2.7) min, the shortest time was 30 minutes and the longest time was no more than 5 minutes. The vital signs were stable before and after treatment and no complications such as arrhythmia. For those 42 successful patients, the average time for jejunal nutrition therapy was (36.2±4.1) days, the shortest was 27 days while the longest was 53 days and no adverse cases occurred. Conclusion: Enteral nutrition has a clinical application on patients with severe craniocerebral injury and can meet the nutritional needs of patients. Moreover, it has a high degree of feasibility and safety which is conducive to the early recovery of patients and has been well received.