Objective: To evaluate the clinical efficacy of combination of surgery and rehabilitation for patients with scar contracture after hand burn. METHODS: Subjects of data calculation in this study were 66 patients with scar contracture after hand burn who were admitted from May 2018 to May 2019. The subjects were divided into regular group and combined group according to random number table method. The regular group (n=33) received surgical treatment alone. The combined group (n=33) patients were given surgery combined with rehabilitation. Recovery of hand function, efficacy of clinical treatment, hand function recovery and ADL score were calculated and compared between the two groups of patients with scare contracture after hand burn. RESULTS: Efficacy, recovery of hand function (finger, finger flexion and extension, palm and finger adduction or abduction, daily activity, wrist rotation, wrist flexion and extension, appearance and sensory function) and ADL score were more superior in combined group when compared with regular group patients with scar contracture after hand burn. P <0.05, the indicator data showed statistical significance. Conclusion: Surgery combined with rehabilitation therapy shown significant value for patients with scar contracture after hand burn.