Keywords
Finasteride
Androgenetic alopecia
Submitted : 2024-08-27
Accepted : 2024-09-11
Published : 2024-09-26
Abstract
Objective: To explore the clinical efficacy and safety of Chuzhi Shengfa tablets combined with finasteride in the treatment of male androgenetic alopecia (AGA). Methods: Sixty male patients with androgenetic alopecia admitted to our Department of Dermatology between January 2022 and January 2024 were randomly divided into two groups, with 30 patients in each group. The control group was treated with finasteride, while the observation group received a combination of Chuzhi Shengfa tablets and finasteride. The clinical efficacy and adverse reactions in both groups were compared. Results: The overall effectiveness rate in the observation group was 93.33% (28/30), significantly higher than the control group’s 73.33% (22/30), with a statistically significant difference (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The combination of Chuzhi Shengfa tablets and finasteride shows good clinical efficacy in treating male androgenetic alopecia. Additionally, Chuzhi Shengfa tablets are convenient to administer and effectively improve efficacy, significantly improving patients’ conditions, and demonstrating good clinical application value.
References
Dong J, Wan M, Feng Z, et al., 2012, Preliminary Study on the Proliferation and Apoptosis of Hair Follicle Stem Cells in Male Patients with Androgenetic Alopecia. Chinese Journal of Aesthetic Medicine, 21(3): 403–405.
Huang T, Wan M, Dong J, et al., 2012, Study on Androgen Receptor Expression in the Scalp of Male Pattern Baldness Patients. Chinese Journal of Aesthetic Medicine, 21(5): 778–781.
Liu Y, Zhang K, Yang X, 2013, Research Progress on the Pathogenesis and Treatment of Androgenetic Alopecia. Chinese Journal of Aesthetic Medicine, 22(17): 1819–1822.
Ceruti JM, Leiros GJ, Balana ME, 2018, Androgens and Androgen Receptor Action in Skin and Hair Follicles. Mol Cell Endocrinol, 465: 122–133. https://doi.org/10.1016/j.mce.2017.09.009
Xu F, Yang Q, Zhou J, et al., 2006, Quality of Life Survey and Analysis of 526 Cases of Androgenetic Alopecia. Journal of Capital Medical University, 2006(6): 740–742.
Wang TL, Zhou C, Shen YW, et al., 2010, Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities. Br J Dermatol, 162(4): 843–847. https://doi.org/10.1111/j.1365-2133.2010.09640.x
Iamsumang W, Leerunyakul K, Suchonwanit P, 2020, Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date. Drug Des Devel Ther, 14: 951–959. https://doi.org/10.2147/DDDT.S240615
Dong J, Zhang G, Huang X, 2014, Treatment of Early Male Androgenetic Alopecia with Chuzhi Shengfa Tablets Combined with Licorice Zinc Granules. Chinese Journal of Aesthetic Medicine, 23(10): 846–848.
Caserini M, Radicioni M, Leuratti C, et al., 2016, Effects of A Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia. Int J Clin Pharmacol Ther, 54(1): 19–27. https://doi.org/10.5414/CP202467
Zhou J, 2017, Treatment of Male Androgenetic Alopecia with Chuzhi Shengfa Tablets Combined with Compound Fluocinolone Acetonide Tincture. Chinese Journal of Aesthetic Medicine, 26(7): 73–74 + 141.
Pan F, Chen M, Yi B, et al., 2024, Treatment of Androgenetic Alopecia in Mice with Processed Polygonum multiflorum via Activation of the Wnt/Beta-catenin Signaling Pathway. Chinese Journal of Experimental Traditional Medical Formulae, online first, 1–8.