Keywords
Vitamin D
EGFR gene polymorphism
Submitted : 2024-08-10
Accepted : 2024-08-25
Published : 2024-09-09
Abstract
Vitamin D is a kind of fat-soluble vitamin, which is mainly involved in the metabolism of calcium and bone in the human body. As a metabolic substance, it also has a certain impact on the cellular microenvironment, and vitamin D also inhibits the proliferation of tumor cells. 25(OH)D is considered the best index to evaluate the vitamin D level in the human body because of its relatively stable characteristics in the circulation. Thyroid cancer is a common malignant tumor that develops from malignant thyroid nodules. A large number of studies have found that the lower the serum 25(OH)D level, the higher the risk of thyroid nodules. A large number of studies have found that the lower the serum 25(OH)D level, the higher the risk of thyroid nodules.
References
Wu S, Liu F, 2023, Research Progress of STAT3 in Thyroid Cancer. Life Science, 35(7): 876–882.
Sung H, Ferlay J, Siegel RL, et al., 2021, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71: 209–249.
Wang Q, 2007, Pathogenesis, Diagnosis and Treatment of Thyroid Cancer, thesis, Zhengzhou University.
Xing H, Lv Y, 2022, The Significance of Combined Detection of Thyroid Stimulating Hormone Thyroglobulin and Vascular Endothelial Growth Factor in the Evaluation of Postoperative Metastasis of Thyroid Cancer. Journal of Practical Medical Technology, 29(9): 942–944+1009.
Wang H, Lin Y, Lin W, et al., 2008, Clinical Significance of Serum VEGF in Advanced Malignant Tumors, Journal of Clinical Oncology, 13(2): 126–128.
Xie Z, Cheng Q, Ding Y, 2018, Metabolism and Effect of Vitamin D. Chinese Journal of Osteoporosis and Bone Mineral Diseases, 11(1): 26–33.
Liu W, Zheng H, 2012, Research Progress on the Relationship Between Vitamin D and Thyroid Cancer. Hebei Medicine, 44(15): 2369–2374.
Yao X, Wang Y, Tang W, 2020, Research Progress on the Role of Wnt Signaling Pathway in Stroke. Journal of Shanxi University of Traditional Chinese Medicine, 21(4): 306–309.
Liu J, Xiao Q, Xiao J, et al., 2012, The Wnt/Beta-Catenin Signalling: Function, Mechanisms, and Therapeutic Opportunities. Signal Transduction and Targeted Therapy, 7(1): 3.
Colozza G, Koo DE, 2021, Defending Wnt/Beta-Catenin Signaling: Structure, Assembly, and Endocytosis of the Signalosome. Development, Growth & Differentiation, 63(3): 199–218.
Sha Y, Huang J, Lu Z, et al., 2019, Vitamin D Inhibits the Activity of Breast Cancer Stem Cells by Regulating Wnt/Beta-catenin Signaling Pathway. Chinese Journal of Cancer Prevention and Treatment, 11(4): 297–302.
Li C, Xue Y, Wang Y, 2023, The Influencing Factors of Postoperative Infection in Elderly Gastric Cancer Patients and Their Association with the Expression of c-myc and cyclinD1 mRNA in Cancer Tissue. Chinese Journal of Hospital Infection, 33(11): 1655–1659.
Song Z, Wang J, Hu J, et al., 2015, Yiqi-Huoxue Decoction and Bushen Shengsui Decoction on the Expression of Wnt3a, Frizzled9, and TCF3 in Hippocampus of Rats with Focal Cerebral Ischemia-Reperfusion. Journal of Beijing University of Chinese Medicine, 38(3): 190–194 + 220.
Zhu F, Fan H, 2019, miR-155 Affects the Expression of E-cadherin and Snail in Colonic Tissues of Ulcerative Colitis Through Wnt/Beta-catenin Signaling Pathway. Journal of Huazhong University of Science and Technology (Medical Edition), 48(6): 631–636.
Ghahhari NM, Babashah S, 2015, Interplay Between microRNAs and WNT/Beta-Catenin Signaling Pathway Regulates. European Journal of Cancer, 51(12): 1638–1649.
Bai Z, Wu Q, Zhang C, et al., 2021, Effects of YAP1 and SFRP2 Overexpression on the Biological Behavior of Colorectal Cancer Cells and Their Molecular Mechanisms. Journal of Gastrointestinal Oncology, 12(4): 1601–1612.
Gao Y, Lu H, He S, et al., 2021, SFRP2 Inhibits the Migration of Glioma Cell Line U251 by Down-Regulating Wnt/Beta-Catenin Pathway. Advances in Modern Biomedicine, 21(16): 3007–3010 + 3037.
Chang X, 2023, A Preliminary Study on the Relationship Between 25-Hydroxyvitamin D and Clinical Characteristics of Colorectal Cancer and Its Anti-Colorectal Cancer Development Mechanism, thesis, Ningxia Medical University.
Feldman D, Krishnan AV, Swami S, et al., 2014, The Role of Vitamin D in Reducing Cancer Risk and Progression. Nature Reviews Cancer, 14(5): 342–357.
Feng H, Zhang X, Xiong J, et al., 2021, Research Progress on the Mechanism of Long Non-Coding RNA in Renal Cell Carcinoma. Medical Review, 27(2): 287–292.
Jiang K, Li G, Chen W, et al., 2020, Plasma Exosomal miR-146b-5p and miR-222-3p Are Potential Biomarkers for Lymph Node Metastasis in Papillary Thyroid Carcinomas. Oncotargets and Therapy, 13(2): 1311–1319.
Ye W, Deng X, Fan Y, 2019, Exosomal miRNA423-5p Mediated Oncogene Activity in Papillary Thyroid Carcinoma: A Potential Diagnostic and Biological Target for Cancer Therapy. Neoplasma, 66(4): 516–523.
Chi Q, Wang Y, Zhao W, et al., 2013, Expression of miR-146a in Papillary Thyroid Carcinoma Tissues and Peripheral Blood. Chinese Journal of Endocrinology Surgery, (1): 56–59.
Ma W, Zhao X, Liang L, et al., 2017, miR-146a and miR-146b Promote Proliferation. Oncotarget, 8(17): 28028.
Sasanakietkul T, Murtha TD, Javid M, et al., 2018, Epigenetic Modifications in Poorly Differentiated and Anaplastic Thyroid Cancer. Molecular and Cellular Endocrinology, 469(5): 23–37.
Bu Q, You F, Pan G, et al., 2017, miR-125b Inhibits Anaplastic Thyroid Cancer Cell Migration and Invasion by Targeting PIK3CD. Biomedicine & Pharmacotherapy, 88(4): 443–448.
Wang Y, Cen A, Yang Y, et al., 2021, miR-181a, Delivered by Hypoxic PTC-Secreted Exosomes, Inhibits DACT2 by Downregulating MLL3, Leading to YAP-VEGF-Mediated Angiogenesis. Molecular Therapy-Nucleic Acids, 24: 610–621.
Zhang J, Ma Y, Zhang S, et al., 2018, Differential Diagnosis of Thyroid Follicular Carcinoma and Papillary Thyroid Carcinoma by Plasma miRNA-21. Chinese Journal of Lab Surgery, 35(10): 1921–1923.
Ye Z, Xia X, Xu P, et al., 2022, The Prognostic Implication of the BRAF V600E Mutation in Papillary Thyroid Cancer in a Chinese Population. International Journal of Endocrinology, 2: 6562149.
Lv M, Zhang X, Li M, et al., 2013, miR-26a and Its Target CKS2 Modulate Cell Growth and Tumorigenesis of Papillary Thyroid Carcinoma. PLoS One, 8: e67591.
Geraldo MV, Yamashita AS, Kimura ET, 2012, miR-146b-5p Regulates Signal Transduction of TGF-Beta by Repressing SMAD4 in Thyroid Cancer. Oncogene, 31(15): 1910–1922.
Zhang Q, Guo M, Zhang T, et al., 2020, Research Progress on the Anti-Cancer Mechanism of Vitamin D and Its Receptor Mediated MicroRNA. Journal of Shaanxi University of Science and Technology (Natural Science Edition), 36(6): 60–68.
Sarkar S, Chopra S, Rohit MK, et al., 2016, Vitamin D Regulates the Production of Vascular Endothelial Growth Factor: A Triggering Cause in the Pathogenesis of Rheumatic Heart Disease? Medical Hypotheses, 95: 62–66.
Huang C, Shen Z, 2002, The Study of Vascular Endothelial Growth Factor and Its Application in Tissue Repair. Chinese Journal of Reparative and Reconstructive Surgery, (1): 64–69.
Wang F, Liu X, 2017, Expression and Clinical Significance of XRCC1 and Vascular Endothelial Growth Factor C (VEGF-C) in Differentiated Thyroid Carcinoma. Journal of Cellular & Molecular Immunology, 33(7): 631–635.
Palmer HG, Larriba MJ, Garcia M, et al., 2005, 1Alpha,25-Dihydroxyvitamin D3 Regulates the Expression of Id1 and Id2 Genes and the Angiogenic Phenotype of Human Colon Carcinoma Cells. Oncogene, 24(43): 6533–6544.
Shen J, Ding H, Du C, et al., 2023, The Diagnostic Value of Spectral CT Imaging in the Depth of Local Invasion of Thyroid Cancer and the Correlation Between Quantitative Parameters and Ki67, VEGF, CD34, EGFR in Tumor Tissue. Advances in Modern Biomedicine, 23(3): 483–488.
Omran OM, 2019, EGFR and CXCR1 Expression in Thyroid Carcinoma in Qassim Region-Saudi Arabia. Pathophysiology, 26(2): 145–151.
Dougherty U, Mustafi R, Sadiq F, et al., 2014, The Renin-Angiotensin System Mediates EGF Receptor-Vitamin D Receptor Cross-Talk in Colitis-Associated Colon Cancer. Clinical Cancer Research, 20(22): 5848–5859.
Penna-Martinez M, Ramos-Lopez E, Stern J, et al., 2009, Vitamin D Receptor Polymorphisms in Differentiated Thyroid Carcinoma. Thyroid, 19: 623–628.
Jolliffe DA, Walton RT, Griffiths CJ, et al., 2016, Single Nucleotide Polymorphisms in the Vitamin D Pathway Associating with Circulating Concentrations of Vitamin D Metabolites and Non-Skeletal Health Outcomes: Review of Genetic Association Studies. Journal of Steroid Biochemistry and Molecular Biology, 164: 18–29.
Peng W, Wang K, Zheng R, et al., 2016, 1,25-Dihydroxyvitamin D3 Inhibits the Proliferation of Thyroid Cancer Stem-Like Cells via Cell Cycle Arrest. Endocrinology Research, 41: 71–80.
Li B, Lv L, Li W, 2020, 1,25-Dihydroxy Vitamin D3 Inhibits the Ras-MEK-ERK Pathway and Regulates Proliferation and Apoptosis of the Cells Papillary Thyroid Carcinoma. Journal of Steroids, 159: 108585.
Kuang J, Jin Z, Chen L, et al., 2012, Serum 25-Hydroxyvitamin D Level is Unreliable as a Risk Factor and Prognostic Marker in Papillary Thyroid Carcinoma. Annals of Translational Medicine, 10(4): 193.