Objective: To observe the effects of remimazolam benzenesulfonate combined with alfentanil during painless gastroenteroscopy in elderly patients. Methods: This study analyzes patients aged 60–85 years old undergoing painless gastroenteroscopy. A total of 140 patients, examined between February 2023 and February 2024, voluntarily participated and were randomly divided into an experimental group and a control group. The control group received alfentanil combined with propofol for anesthesia, while the experimental group received alfentanil combined with remimazolam benzenesulfonate. The relevant indices of both groups were separately analyzed. Results: Patients in the experimental group had a shorter awakening time, a faster discharge rate (P < 0.05), and a shorter examination duration; however, the difference in examination time between the two groups was not statistically significant (P > 0.05). Before anesthesia, there was no significant difference in the basic information and vital signs of the two groups (P > 0.05). Two minutes after anesthesia, both groups showed a decline in vital signs, but the vital signs of the experimental group remained more stable after the procedure, with the group’s indices showing improvement over the control group (P < 0.05). Additionally, the incidence of adverse reactions in the experimental group was lower than in the control group (P < 0.05). Conclusion: In painless gastroenteroscopy for elderly patients, anesthesia using a combination of remimazolam benzenesulfonate and alfentanil improves anesthesia effectiveness, hastens patient recovery, enhances the stability of vital signs, and effectively controls adverse reactions, thereby improving patient comfort.
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