Study on Key Biological Indicators of Diabetes Based on Statistical Tests
Download PDF
$currentUrl="http://$_SERVER[HTTP_HOST]$_SERVER[REQUEST_URI]"

Keywords

Diabetes diagnosis
Statistical test
Nonparametric statistics
Normality test

DOI

10.26689/jcnr.v8i7.7881

Submitted : 2024-07-10
Accepted : 2024-07-25
Published : 2024-08-09

Abstract

Normality testing is a fundamental hypothesis test in the statistical analysis of key biological indicators of diabetes. If this assumption is violated, it may cause the test results to deviate from the true value, leading to incorrect inferences and conclusions, and ultimately affecting the validity and accuracy of statistical inferences. Considering this, the study designs a unified analysis scheme for different data types based on parametric statistical test methods and non-parametric test methods. The data were grouped according to sample type and divided into discrete data and continuous data. To account for differences among subgroups, the conventional chi-squared test was used for discrete data. The normal distribution is the basis of many statistical methods; if the data does not follow a normal distribution, many statistical methods will fail or produce incorrect results. Therefore, before data analysis and modeling, the data were divided into normal and non-normal groups through normality testing. For normally distributed data, parametric statistical methods were used to judge the differences between groups. For non-normal data, non-parametric tests were employed to improve the accuracy of the analysis. Statistically significant indicators were retained according to the significance index P-value of the statistical test or corresponding statistics. These indicators were then combined with relevant medical background to further explore the etiology leading to the occurrence or transformation of diabetes status.

References

Redondo MJ, Hagopian WA, Oram R, et al., 2020, The Clinical Consequences of Heterogeneity Within and Between Different Diabetes Types. Diabetologia, 63(10): 2040–2048. https://doi.org/10.1007/s00125-020-05211-7

Eizirik DL, Pasquali L, Cnop M, 2020, Pancreatic Beta-Cells in Type 1 and Type 2 Diabetes Mellitus: Different Pathways to Failure. Nat Rev Endocrinol, 16(7): 349–362. https://doi.org/10.1038/s41574-020-0355-7

Galicia-Garcia U, Benito-Vicente A, Jebari S, et al., 2020, Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci, 21(17): 6275. https://doi.org/10.3390/ijms21176275

Siqueira ISL, Alves Guimaraes R, Mamed SN, et al., 2020, Prevalence and Risk Factors for Self-Report Diabetes Mellitus: A Population-Based Study. Int J Environ Res Public Health, 17(18): 6497. https://doi.org/10.3390/ijerph17186497

Zeru MA, Tesfa E, Mitiku AA, et al., 2021, Prevalence and Risk Factors of Type-2 Diabetes Mellitus in Ethiopia: Systematic Review and Meta-Analysis. Sci Rep, 11(1): 21733. https://doi.org/10.1038/s41598-021-01256-9

World Health Organization (WHO), Diabetes, viewed June 20, 2023, https://www.who.int/news-room/fact-sheets/detail/diabetes

Yang W, Lu J, Weng J, et al., 2010, Prevalence of Diabetes among Men and Women in China. N Engl J Med, 362(12): 1090–1101. https://doi.org/10.1056/NEJMoa0908292

Patterson CC, Dahlquist GG, Gyurus E, et al., 2009, Incidence Trends for Childhood Type 1 Diabetes in Europe during 1989–2003 and Predicted New Cases 2005–20: A Multicentre Prospective Registration Study. Lancet, 373(9680): 2027–2033. https://doi.org/10.1016/S0140-6736(09)60568-7

Entmacher PS, Marks HH, 1965, Diabetes in 1964; A World Survey. Diabetes, 14: 212–223. https://doi.org/10.2337/diab.14.4.212

Wild S, Roglic G, Green A, et al., 2004, Global Prevalence of Diabetes: Estimates for the Year 2000 and Projections for 2030. Diabetes Care, 27(5): 1047–1053. https://doi.org/10.2337/diacare.27.5.1047

Ogurtsova K, da Rocha Fernandes JD, Huang Y, et al., 2017, IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract, 128: 40–50. https://doi.org/10.1016/j.diabres.2017.03.024

Yokoyama H, Hirasawa K, Aoki T, et al., 2003, Brachial-Ankle Pulse Wave Velocity Measured Automatically by Oscillometric Method is Elevated in Diabetic Patients with Incipient Nephropathy. Diabet Med, 20(11): 942–945. https://doi.org/10.1046/j.1464-5491.2003.01043.x

Lorenz MW, Price JF, Robertson C, et al., 2015, Carotid Intima-Media Thickness Progression and Risk of Vascular Events in People with Diabetes: Results from the PROG-IMT Collaboration. Diabetes Care, 38(10): 1921–1929. https://doi.org/10.2337/dc14-2732

Katsiki N, Mikhailidis DP, 2020, Diabetes and Carotid Artery Disease: A Narrative Review. Ann Transl Med, 8(19): 1280. https://doi.org/10.21037/atm.2019.12.153

Wong ELY, Xu RH, Cheung AWL, 2020, Measurement of Health-Related Quality of Life in Patients with Diabetes Mellitus Using EQ-5D-5L in Hong Kong, China. Qual Life Res, 29(7): 1913–1921. https://doi.org/10.1007/s11136-020-02462-0

Que Y, Cao M, He J, et al., 2021, Gut Bacterial Characteristics of Patients With Type 2 Diabetes Mellitus and the Application Potential. Front Immunol, 12: 722206. https://doi.org/10.3389/fimmu.2021.722206

Li C, Wang D, Jiang Z, et al., 2022, Non-Coding RNAs in Diabetes Mellitus and Diabetic Cardiovascular Disease. Front Endocrinol (Lausanne), 13: 961802. https://doi.org/10.3389/fendo.2022.961802

Guo HJ, Li CC, Bian XY, et al., 2023, Correlation Study on the Relationship between Dyslipidemia and Carotid Intima-Media Thickness in Patients with Diabetes Mellitus. Pak J Med Sci, 39(3): 875–879. https://doi.org/10.12669/pjms.39.3.6866

Diriba DC, Leung DYP, Suen LKP, 2023, Factors Predicted Quality of Life of People with Type 2 Diabetes in Western Ethiopia. PLoS One, 18(2): e0281716. https://doi.org/10.1371/journal.pone.0281716

Liao M, Chen S, Guo R, 2023, Association between Carotid Ultrasonographic Parameters and Microvascular and Macrovascular Complications in Diabetes: A Systematic Review and Meta-Analysis. J Diabetes Complications, 37(8): 108554. https://doi.org/10.1016/j.jdiacomp.2023.108554

Yang M, He L, Liu W, et al., 2024, Performance Improvement of Atherosclerosis Risk Assessment Based on Feature Interaction. Comput Methods Programs Biomed, 249: 108139. https://doi.org/10.1016/j.cmpb.2024.108139