Objective: To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas. Methods: Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings. The conventional group (n=40) received routine treatment and rehabilitation while the rehabilitation group (n=41) was given comprehensive rehabilitation treatment. Thereafter, the recovery of joint function in patients with deep burns in different areas, the combined value of clinical long-term treatment, the recovery of joint function and the score of daily living ability were calculated. Results: The total long-term effective rate of treatment, the recovery of the joint function, and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05, the index data indicating statistical significance. Conclusion: Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.