Objective: To evaluate the therapeutic effect of laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) on cholelithiasis. Methods: 92 cases of cholelithiasis patients admitted to the hospital in the past 2 years were selected and grouped by random number table; the observation group was treated with LC; the reference group was treated with OC, and the inflammatory factor and other indexes were compared. Results: The total effective rate of the observation group was higher than that of the reference group, and the perioperative indexes were better than that of the reference group (P < 0.05). Preoperatively, the C-reactive protein (CRP) and interleukin-1β (IL-1β) levels and immune function indexes of the two groups were compared, and no difference was seen (P >0.05). At 5 days postoperatively, the CRP and IL-1β levels of the observation group were lower than those of the reference group, and the immune function indicators were higher than those of the reference group (P < 0.05). The complication rate of the observation group was lower than that of the reference group (P < 0.05). Conclusion: LC can increase the effective rate of cholelithiasis patients, improve their perioperative indexes, reduce the inflammatory response, protect patients’ immune function, and ensure higher surgical safety.
Sun G, Zhou F, 2021, Comparison of the Effects of Laparoscopic and Open Cholecystectomy in the Treatment of Cholelithiasis in the Elderly. Frontiers of Medicine, 11(31): 62–63.
Li H, 2020, Comparison of Surgical Conditions and Complications Between Open and Laparoscopic Cholecystectomy for the Treatment of Elderly Patients with Cholelithiasis. Medical Equipment, 33(2): 125–126.
Cha T, Sun D, Cai J, 2023, Effects of Laparoscopic and Open Cholecystectomy on Inflammatory Response and Oxidative Stress in Patients with Cholelithiasis. Anhui Medicine, 44(11): 1359–1361.
Li H, 2021, Exploration of the Role of Ultrasonography in Reducing the Rate of Conversion to Open Abdomen in Laparoscopic Cholecystectomy. China Medical Device Information, 27(22): 90–92.
Gao L, 2021, Comparative Analysis of Clinical Application of Laparoscopic Cholecystectomy and Small Incision Open Cholecystectomy. China Metallurgical Industry Medical Journal, 38(4): Seal 2.
Li M, Hu Z, Zhang Z, et al., 2021, Clinical Effect of Laparoscopic Treatment of Complex and Difficult Gallbladder Stones. Chinese Contemporary Medicine, 28(1): 104–107.
Yu Y, Liu R, Chen J, et al., 2019, Laparoscopic Surgery for the Treatment of 120 Cases of Advanced Cholelithiasis Combined with Schistosomal Cirrhosis. Journal of Hepatobiliary and Pancreatic Surgery, 31(10): 626–628.
Meng Y, 2020, Nursing Experience After Laparoscopic Cholecystectomy and Traditional Cholecystectomy. Dietary Health Care, 7(9): 101–102.
Xu W, Cheng L, 2020, Observation on the Effect of Laparoscopic Cholecystectomy in the Treatment of Gallstones. Journal of Shandong Medical College, 42(3): 215–216.
Dai Y, Wang D, 2019, Combined Treatment of Cholelithiasis with Three Mirrors. Advances in Modern General Surgery in China, 22(8): 631–632, 635.
Sun Y, Shang P, Zhang W, 2023, Clinical Experience of Laparoscopic Closure of Cholecystoduodenal Fistula Using Gallbladder Wall Masking. Journal of Laparoscopic Surgery, 28(12): 906–910.