Exploration of Therapeutic Measures and Clinical Efficacy for Recurrent Respiratory Infections in Children

Abstract

Objective: To explore the treatment strategies and clinical effects for recurrent respiratory infections in children. Methods: From May 2022 to May 2024, 100 pediatric patients with recurrent respiratory infections were selected in this study and evenly divided into two groups. The control group (50 patients) was treated with conventional therapy supplemented with budesonide, while the observation group (50 patients) received pidotimod treatment in addition to the control group’s treatment. Subsequently, the duration of clinical symptom improvement, respiratory function enhancement, serological index changes, reinfection status, and parental satisfaction were compared between the two groups. Results: In terms of clinical symptoms, the observation group showed significantly shorter durations of fever reduction, cough relief, tonsil swelling reduction, and disappearance of fine wet rales compared to the control group (average reduction times were 1.6 days, 2.3 days, 2.1 days, and 1.9 days, respectively, P < 0.05). Regarding respiratory function, the observation group experienced a 12% increase in peak expiratory flow rate variability, a 0.6-liter increase in lung capacity, a 0.7-liter increase in forced lung capacity, and a 0.5-liter increase in forced expiratory volume in the first second after treatment, all significantly higher than the control group (P < 0.05). Serological testing revealed that interferon-γ and interleukin-2 levels increased by 15% and 18%, respectively, while interferon-α, interleukin-5, and interleukin-4 levels decreased by 10%, 12%, and 9%, respectively, in the observation group, showing significant differences compared to the control group (P < 0.05). Additionally, the reinfection rate in the observation group (10%) was significantly lower than that in the control group (30%), with an average reduction of two reinfections within one year and a 3.2-day shorter infection control time (P < 0.05). In terms of parental satisfaction, the observation group achieved 95%, significantly higher than the 70% in the control group (P < 0.05). Conclusion: The addition of pidotimod to conventional therapy for pediatric patients with recurrent respiratory infections can significantly alleviate clinical symptoms, promote the recovery of respiratory function, regulate serological indicators, effectively reduce the risk of reinfection, and improve parental satisfaction. This method deserves widespread clinical application.