Correlation Analysis Between Changes of D-Dimer Level and Rheumatoid Arthritis Complicated with Interstitial Lung Disease

Abstract

Objective: To explore the correlation between the change of D-dimer level and rheumatoid arthritis complicated with interstitial lung disease. Methods: From January 2022 to February 2024, 20 rheumatoid arthritis patients complicated with interstitial lung disease (interstitial lung disease group), 20 rheumatoid arthritis patients without interstitial lung disease (without interstitial lung disease group), and 20 healthy people (control group) in Xijing Hospital were selected for this study. The fasting venous blood of the three groups of subjects was collected and their D-dimer, C-reactive protein (CRP), rheumatoid factor (RF), and erythrocyte sedimentation rate (ESR) were detected. Subsequently, the correlation between each index and rheumatoid arthritis complicated with interstitial lung disease was analyzed. Results: The D-dimer level of the interstitial lung disease group was significantly higher than the other two groups (P < 0.05). The D-dimer level of the group without interstitial lung disease was significantly higher than the control group (P < 0.05). CRP levels in the interstitial lung disease group and the group without interstitial lung disease were significantly higher than those of the control group (P < 0.05). The ESR and RF levels of the interstitial lung disease group were significantly higher than the other two groups (P < 0.05). The levels of ESR and RF levels of the group without interstitial lung disease were significantly higher than the control group (P < 0.05). Conclusion: D-dimer levels of rheumatoid arthritis patients are higher than those of healthy individuals, and those complicated with interstitial lung disease present even higher levels. This finding shows that there is a correlation between D-dimer levels and rheumatoid arthritis with interstitial lung disease, which may facilitate the evaluation and diagnosis of this disease.