Keywords
Immunizations
COVID-19 inactivated vaccine (Vero cell)
Immune thrombocytopenic purpura
Investigation and diagnosis
Submitted : 2024-06-18
Accepted : 2024-07-03
Published : 2024-07-18
Abstract
Objective: Analyze the relationship between inoculating one case of the COVID-19 inactivated vaccine (Vero cell) and immune thrombocytopenic purpura to provide a reference for the standardized handling of adverse events following immunization. Methods: According to the “National Monitoring Program for Suspected Adverse Reactions to Vaccinations,” an on-site investigation, data collection and analysis, expert group diagnosis, and medical association assessment were conducted on a case of immune thrombocytopenic purpura in District A of Chongqing after vaccination with the inactivated COVID-19 vaccine. The assessment report was delivered to the three relevant parties, the case was reviewed, and the experience was summarized. Results: The investigation and diagnosis by the district-level vaccination abnormal reaction expert group concluded that the disease that occurred after vaccination with the COVID-19 inactivated vaccine was secondary immune thrombocytopenic purpura, an abnormal reaction to the vaccination. The medical damage was classified as Level II Grade B. The vaccine production enterprise raised objections to this conclusion. After re-assessment by the municipal-level medical association, the conclusion was consistent with that of the district-level medical association. The vaccine production enterprise did not raise any further objections. Conclusion: Through active collaboration among district and municipal-level medical associations, disease control institutions, and vaccination units, the recipients have been promptly and effectively treated, providing financial support for their subsequent treatment and safeguarding their rights. The investigation and disposal procedures for adverse events following immunization in Chongqing are clear, and the mechanism is sound. It is necessary to continue strengthening the monitoring of adverse events following immunization according to the existing plan and to ensure timely and standardized handling. Simultaneously, it is crucial to strengthen vaccine management and vaccination management.
References
Pan F, 2019, Vaccination is the Most Effective Measure to Prevent Infectious Diseases: Interview with Professor Zeng Guang of the Chinese Center for Disease Control and Prevention. Contemporary Chinese Medicine, 26(5): 1–3.
Ma C, An Z, Wang F, et al., 2021, Prevention First Serves the Health and a Century of Building an Immune Wall: A Review of Immunization Planning Work and Achievements Since the Founding of the Communist Party of China 100 Years Ago. Chinese Journal of Vaccines and Immunization, 27(6): 609–614 + 638.
Wong WHS, Leung D, Chua GT, et al., 2022, Adolescents’ Attitudes to the COVID-19 Vaccination. Vaccine, 40(7): 967–969.
Cheng X, Yan W, Wang X, et al., 2023, Comparative Analysis of Factors Affecting COVID-19 Vaccine Hesitancy in China. Chinese Journal of Social Medicine, 40(4): 431–436.
Rodeghiero F, Stasi R, Gernsheimer T, et al., 2009, Standardization of Terminology, Definitions and Outcome Criteria in Immune Thrombocytopenic Purpura of Adults and Children: Report from an International Working Group. Blood, 113(11): 2386–2393.
Ma L, Yang Z, Wang Y, 2024, Current Status and Prospects of Global Vaccine Research and Development. Journal of China Pharmaceutical University, 55(1): 115–126.
Chai F, Zhang R, Cao L, et al., 1995, Analysis of the National Poliomyelitis Epidemic Situation in 1994. Chinese Journal of Epidemiology, 16(6): 338–342.
Ma C, Luo H, An Z, et al., 2008, Analysis of Epidemiological Characteristics of Measles and Measures to Eliminate Measles in China from 2006 to 2007. Chinese Vaccines and Immunization, 2008(3): 208–213.
Hao L, Ma C, Ma J, et al., 2010, Analysis of Epidemiological Characteristics of Measles in China from 2008 to 2009. Chinese Journal of Vaccines and Immunization, 16(4): 293–296 + 370.
Fu Y, Bie F, He L, et al., 2021, Implementation Results of the Immunization Program in China. Chinese Journal of Clinical Research, 34(11): 1599–1601.
Sun L, Shi Y, Xu W, 2012, Investigation on the Cognition of Suspected Abnormal Reactions to Vaccination Among Primary Health Care Workers in a Certain District. Modern Preventive Medicine, 39(2): 340–341 + 344.
Liu X, Xiao W, Gong F, et al., 2010, Investigation and Analysis of Human Resources Status of Huizhou City’s Adverse Reaction Monitoring System for Immunization. Chinese Journal of Medicine, 12(4): 714–715.