Research Progress in Early-onset Colorectal Cancer

Abstract

Colorectal cancer used to be a common disease among middle-aged and elderly people. In recent years, the incidence of colorectal cancer (Early-onset colorectal cancer, EOCRC) under 50 years old has increased year by year. Different from the traditional late-onset colon cancer (LOCRC), the diagnosis stage of EOCRC is mostly in the late stage, with poor cell differentiation and poor diagnosis, and there is a layer of consensus and guidance on the diagnosis, treatment or screening of EOCRC at presentation. Therefore, fully understanding the disease characteristics and risk exposure factors of EOCRC is helpful to guide early screening and treatment, which ultimately reduces the mortality of EOCRC. In this review article, we summarized the epidemiology, physiology, risk exposure factors and pathological diagnosis of EOCRC, and discussed the diagnosis and treatment prospect of EOCRC.