Effectiveness of Atorvastatin Combined with Trimetazidine in the Treatment of Coronary Heart Disease in the Elderly and Their Effect on Cardiac Function
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Keywords

Coronary heart disease in the elderly
Atorvastatin
Trimetazidine
Cardiac function

DOI

10.26689/jcnr.v8i5.7354

Submitted : 2024-05-26
Accepted : 2024-06-10
Published : 2024-06-25

Abstract

Objective: To analyze the effect of atorvastatin combined with trimetazidine in the treatment of elderly coronary artery disease and the effect on patients’ cardiac function. Methods: 60 cases of elderly coronary artery disease patients were divided into 2 groups by randomization method, and all of them received conventional symptomatic treatment, while atorvastatin was added to the control group and trimetazidine was combined with atorvastatin in the observation group, and the clinical indexes were compared. Results: After treatment, the angina attack, cardiac function indexes, and inflammatory factor levels of the observation group were better than those of the control group (P < 0.05), and the differences in adverse reactions between the two groups were not significant (P > 0.05). Conclusion: Combined treatment of coronary heart disease in the elderly with atorvastatin and trimetazidine can positively reduce angina symptoms, improve cardiac function, and reduce inflammatory reactions, and the effect is definite.

References

Ye S, Lu W, Li Y, 2023, Efficacy of Trimetazidine Combined with Atorvastatin in the Treatment of Angina Pectoris in Elderly Coronary Artery Disease and the Effects on Electrocardiographic Parameters, Ultrasound Parameters and Cytokines. Chinese Journal of Gerontology, 43(17): 4100–4103.

Zhao W, Zuo Y, 2023, Efficacy of Atorvastatin Combined with Aspirin in the Treatment of Menopausal Patients with Coronary Artery Disease and Analysis of the Effects on Bone Biochemistry and Metabolism. Guizhou Medicine, 47(3): 389–390.

Zhou L, Li J, Zheng X, 2023, Clinical Efficacy of Different Doses of Statins Combined with Trimetazidine in the Treatment of Coronary Heart Disease Combined with Hypercholesterolemia. Cardiovascular and Cerebrovascular Disease Control, 23(3): 44–46.

Cao J, Qin J, Chen W, et al., 2022, Effects of Trimetazidine on Psychological Stress Myocardial Ischemia in Patients with Stable Coronary Artery Disease and Anxiety. Journal of Integrative Cardiovascular and Cerebrovascular Disease, 20(23): 4318–4321.

Liu Y, Liu Y, Zhu J, et al., 2022, Effect of Tongxinluo Combined with Trimetazidine on Ventricular Remodeling and Left Heart Function in Patients with Coronary Heart Failure. Modern Journal of Integrative Medicine, 31(8): 1120–1123.

Sun J, Yang M, Fan Y, 2023, Application Value of Yixinshu Tablets Combined with Trimetazidine in Patients with Angina Pectoris of Coronary Heart Disease. Clinical Misdiagnosis and Mistreatment, 36(8): 132–136.

Wu R, 2022, Effect of Trimetazidine and Nicorandil in the Treatment of Type 2 Diabetes Mellitus Combined with Coronary Artery Disease and Its Effect on Patients’ Lipocalin and Inflammatory Factor. Cardiovascular and Cerebrovascular Disease Control, 22(2): 81–84.

Zhang L, Li J, 2022, Effects of Metoprolol Combined with Trimetazidine on Oxidative Stress Level and Exercise Tolerance in Patients with Coronary Artery Disease. Journal of Integrative Cardiovascular and Cerebrovascular Disease, 20(4): 705–708.

Wan Z, 2023, Effect of PCI Combined with Atorvastatin Calcium on Myocardial Injury Indexes in Patients with Coronary Heart Disease Combined with Renal Insufficiency. Chinese Journal of Gerontology, 43(11): 2566–2569.

Wang Y, Lai Z, Luo Y, et al., 2023, Efficacy of Different Doses of Atorvastatin in the Treatment of Coronary Artery Disease in the Elderly and Its Effects on Ventricular Remodeling, Platelet Activation Status and Blood Rheology. Chinese Journal of Gerontology, 43(22): 5386–5389.

Chen Z, Huang X, Xiao S, 2023, Effects of Tongxinluo Capsule Combined with Atorvastatin Treatment on Lipid Levels and Cardiac Function in Elderly Patients with Coronary Heart Disease. Chinese Journal of Gerontology, 43(13): 3086–3088.

Hu B, Wang W, Dai M, 2023, Clinical Study of Sacubitril Valsartan Sodium Tablets Combined with Atorvastatin Calcium Tablets in the Treatment of Hypertension Combined with Coronary Heart Disease. Journal of Integrated Cardiovascular and Cerebrovascular Diseases of Chinese and Western Medicine, 21(17): 3217–3220.