Keywords
Sepsis
Nutritional support
Immune function index
Regression
Submitted : 2024-05-26
Accepted : 2024-06-10
Published : 2024-06-25
Abstract
Objective: To evaluate the therapeutic efficacy of alanyl-glutamine (Ala-Gln) in the nutritional support of sepsis. Methods: 120 cases of sepsis patients admitted to the hospital in the past three years were selected and grouped by randomization method, Group A was treated with Ala-Gln, and Group B was treated with conventional nutritional support therapy, and the therapeutic effects were compared. Results: Before treatment, there was no difference in nutritional indexes, immune function indexes, and inflammatory factors between the two groups (P > 0.05). After treatment, the nutritional indexes of Group A were higher than those of Group B, the immune function indexes were higher than those of Group B, and the inflammatory factors were lower than those of Group B (P < 0.05). Except for mortality, the regression of group A was better than that of group B (P < 0.05). Conclusion: Ala-Gln can improve the nutritional indexes of septicemia patients during the treatment period, enhance their immune function, reduce the inflammatory response of the body, and promote the regression of the disease.
References
Huang Z, He L, Huang Y, et al., 2023, Effectiveness of Alanyl-Glutamine Intensive Nutritional Support in Patients with Intestinal Obstruction. Northwest Journal of Pharmacy, 38(5): 130–134.
Xu C, Li B, Xing M, et al., 2021, Protective Effect of Growth Inhibitor Combined with Alanyl-Glutamine on Intestinal Function in Patients with Sepsis. Journal of Clinics and Pathology, 41(5): 7.
Liang H, Ge J, Liu T, et al., 2023, A Randomized Controlled Clinical Trial Comparing Different Concentrations of Alanyl-Glutamine for Parenteral Nutrition in Postoperative Patients with Gastrointestinal Tumors. Chinese Journal of General Surgery, 32(10): 1539–1551.
Shan L, Chen J, Xiao J, et al., 2019, Effects of Alanyl-Glutamine-Assisted Enteral and Parenteral Nutrition on Gastrointestinal Hormones, Inflammatory Cytokine Levels and Growth and Development in Very Low Birth Mass Children. China Maternal and Child Health, 34(24): 4.
Zhou Q, 2024, Observation on the Effect of Alanyl-Glutamine Used for Sepsis Nutritional Support. Clinical Rational Drug Use, 17(1): 101–103.
Lv Z, Lin X, 2021, Clinical Efficacy of Nutritional Support Combined with Alanyl-Glutamine in the Treatment of Sepsis and Its Effect on GSH and Gln. Straits Pharmacology, 33(8): 150–152.
Li Y, 2021, Effect of Probiotics Combined with Alanyl-Glutamine on Acute Intestinal Mucosal Injury and Glutathione and Glutamine Levels in Sepsis. Heilongjiang Medicine, 45(3): 283–285.
Min T, Gao H, Qu D, et al., 2019, Effectiveness of Alanyl-Glutamine in Nutritional Supportive Therapy in Patients with Sepsis. China Healthcare Nutrition, 29(22): 314.
Freitas AKL, Silva MTB, Silva CMS, et al., 2020, Alanyl-Glutamine Protects the Intestinal Barrier Function in Trained Rats Against the Impact of Acute Exhaustive Exercise. Braz J Med Biol Res, 53(5): e9211. https://doi.org/10.1590/1414-431X20209211
Ping W, Wang Z, Chen L, et al., 2020, Effects of Alanyl-Glutamine Dipeptide and Mannan Oligosaccharides on Intestinal Morphology and Microflora Structure in Weaned Piglets. Chinese Journal of Animal Nutrition, 32(10): 4862–4872.