Keywords
Chronic obstructive pulmonary disease
Acute exacerbation
Multidrug-resistant Acinetobacter baumannii infection
Submitted : 2024-05-29
Accepted : 2024-06-13
Published : 2024-06-28
Abstract
Objective: To study the clinical efficacy and safety of tigecycline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) combined with multidrug-resistant Acinetobacter baumannii infection. Methods: 113 patients with acute exacerbation of COPD combined with multidrug-resistant Acinetobacter baumannii infection were recruited between January 2021 and January 2023, and given tigecycline treatment. The total effective rate, lung function indexes, related biochemical index levels, and the incidence rate of adverse reactions were observed after the treatment. Results: After the treatment, 100 patients were cured, 1 case with apparent effect, 2 cases were effective, 10 cases were ineffective, and the total effective rate was 91.15%. The post-treatment CRP (21.22 ± 3.35 mg/L), PCT (3.18 ± 1.11 ng/L), CRE (76.36 ± 9.24 μmol/L), and ALT (37.76 ± 6.99 U/L) were significantly improved as compared to the pre-treatment (P < 0.05). After treatment, 10 cases of vomiting (8.85%), 13 cases of nausea (11.50%), 4 cases of diarrhea (3.53%), 1 case of abdominal pain (0.88%), and 2 cases of allergy (1.77%) were observed in 113 patients. Conclusion: Tigecycline therapy for patients with acute exacerbation of COPD combined with multidrug-resistant Acinetobacter baumannii infection not only has significant therapeutic efficacy but also has a high degree of safety.
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