Keywords
Asthma
Intestine flora
Antibiotics
Influencing factors
Submitted : 2024-05-21
Accepted : 2024-06-05
Published : 2024-06-20
Abstract
Objective: In order to reveal the potential association between intestinal flora and atopic dermatitis with asthma, the study compares the changes in intestinal flora before and after treatment with antibiotics in children and explores the risk factors for the disease development in children. The differences between asthma-controlled children and healthy children were also analyzed to investigate whether there was a correlation between the level of control and intestinal flora in asthmatic children. Methods: 367 children with atopic dermatitis and asthma were selected, and the control group was healthy children who did not have other skin diseases. Fecal samples were collected from healthy children and children with asthma, and the intestinal flora was tested at Beijing Nebula Medical Testing Laboratory Co. At the same time, 50 children were selected according to the inclusion and exclusion criteria to take amide antibiotics during hospitalization, and stool samples were collected before and after taking antibiotics. Results: The proportion of Gram-positive cocci increased and the proportion of Gram-positive bacilli decreased after the administration of antibiotics in children with atopic dermatitis and asthma (P < 0.05), and no significant difference was shown in the gender and age of the children (P > 0.05). The proportion of family history of atopic dermatitis with asthma was higher in the experimental group (P < 0.05). Conclusion: The use of antibiotics in children with atopic dermatitis with asthma showed a positive correlation with changes in intestinal flora. The use of antibiotics may lead to changes in intestinal flora and increase the risk of atopic dermatitis with asthma. Antibiotic use in infancy and childhood is also recognized as a risk factor for atopic dermatitis with asthma. Therefore, the use of antibiotics should be minimized in preventing and treating atopic dermatitis with asthma.
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