Analysis of the Application Effect and Value of Dydrogesterone in The Treatment of Preeclampsia
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Keywords

Preeclampsia
Fertility preservation treatment
Dydrogesterone
Application effect

DOI

10.26689/jcnr.v8i4.6705

Submitted : 2024-04-16
Accepted : 2024-05-01
Published : 2024-05-16

Abstract

Objective: To analyze the application effect and value of dydrogesterone in the fertility preservation treatment of preeclampsia. Methods: Forty cases of patients with preeclampsia admitted to our hospital between January 2023 and January 2024 were divided randomly into a control group and an observation group of 20 cases each. The control group applied progesterone to preserve the fetus, and the observation group applied dydrogesterone. The symptom relief time, hormone levels before and after treatment, as well as adverse drug reactions, and the effect of fetal preservation between the two groups were compared. Results: The time to relieve vaginal bleeding, abdominal pain. and lumbago in the observation group was shorter than that in the control group (P < 0.05). After treatment, the progesterone levels and incidence of adverse drug reactions in the observation group were lower than those in the control group (P < 0.05). The success rate of fertility preservation in the observation group was higher than that in the control group (P < 0.05). Conclusion: In the treatment of fetal preservation of preeclampsia, the application of dydrogesterone positively alleviated vaginal bleeding, abdominal pain, and lumbago, with mild adverse reactions and a good effect on fetal preservation.

References

Li Y, Sun G, 2023, Effect of Solidifying Yuan and Stabilizing the Fetus Soup Combined with Dydrogesterone in Treating Renal Deficiency in Preeclampsia and Its Effect on Uterine Arterial Blood Flow and Endocrine Indexes. Chinese Journal of Family Planning, 31(10): 2332–2337.

Chen J, Dang X, Yao Z, 2022, Efficacy of Dydrogesterone Tablets in The Treatment of Preeclampsia Due to Luteal Insufficiency. Chinese Journal of Family Planning, 30(12): 2807–2811.

Wei Z, Yang C, Wan Y, et al., 2022, Efficacy of Tonifying the Kidney, Resolving Blood Stasis, and Stabilizing the Fetus Formula Combined with Dydrogesterone in The Treatment of Early Preeclampsia Combined with Subchorionic Hematoma and its Effect on Progesterone, Chorionic Gonadotropin, and Immunoinflammatory Factors. Modern Journal of Integrative Medicine, 31(14): 1973–1976.

Pan J, Fang Y, Yan H, et al., 2022, Effect of Zi Ren Yu Fetal Pill Combined with Difenzo-pregnenolone on HCG level and Bleeding Area in Patients with Subchorionic Hematoma with Preeclampsia. Journal of Hubei University of Traditional Chinese Medicine, 24(5): 77–79.

Yang Q, Huang Y, 2022, Study on the Effects of Dexmedetomidine Combined with Progesterone on The Success of Fetal Preservation, Hormone Level Changes and Efficacy of Preeclampsia. Guizhou Medicine, 46(2): 203–204.

Pi A, Zhou Q, Zeng C, 2022, Treatment of Preeclampsia Combined with Uterine Hematochezia by Tonifying Kidney and Activating Blood Combined with Dydrogesterone Tablets. World TCM, 17(3): 408–412.

Han L, Xu Q, 2022, Research on Constructing a Model of The Effect of Dydrogesterone in The Treatment of Preeclampsia Based on The XGBoost Algorithm. Chinese Sexual Science, 31(8): 117–121.

Liang Y, Liang H, Lu C, et al., 2021, Observation on the Therapeutic Effect of Tonifying Kidney and Activating Blood Formula Combined with Dydrogesterone in The Treatment of Early Preeclampsia Combined with Subchorionic Hematoma. Hainan Medicine, 32(16): 2084–2087.

Li H, Du E, 2022, Effect of Fetal Preservation Capsule Combined with Dydrogesterone on Progesterone Human Chorionic Gonadotropin Level and Coagulation Function in Patients with Preeclampsia. China Maternal and Child Health Care, 37(15): 2830–2833.

Wang Y, Zhang J, Ma F, 2022, Effect of Dydrogesterone Combined with Estradiol Valerate Tablets on Hormone Level Hemodynamics and Pregnancy Outcome in Patients with Preeclampsia. China Maternal and Child Health Care, 37(16): 3013–3017.

Zhang Y, Qi Z, Zhang X, 2021, Effects of Tonifying the Kidney, Strengthening the Spleen, and Stabilizing The Fetus in Combination with Oral Treatment with Dydrogesterone Tablets on Maternal and Infant Outcomes and Quality of Life in Pregnant Women with Renal Deficiency-Type High-Risk Preeclamptic Miscarriage in Early Pregnancy. Medical Clinical Research, 38(9): 1321–1323 + 1327.

Ma X, Feng C, Li Y, et al., 2021, Factors Affecting the Effectiveness of Dexmedetomidine in The Treatment of Early Preeclampsia and The Follow-Up Study of Pregnancy Outcome. Modern Biomedical Progress, 21(24): 4672–4675 + 4680.

Pang YY, Ma CL, 2022, Real-World Pharmacological Treatment Patterns of Patients with Threatened Miscarriage in China from 2014 to 2020: A Cross-Sectional Analysis. Journal of Clinical Pharmacy and Therapeutics, 47(2): 228– 236.