Nanobioceramics for Tissue Engineering Application
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Keywords

Nanobioceramics
Bone repair
Orthopedic and dental application

DOI

10.26689/jcnr.v8i6.6438

Submitted : 2024-06-18
Accepted : 2024-07-03
Published : 2024-07-18

Abstract

Nanobiomaterials demonstrate great potential in bone and dental tissue regeneration. These materials mimic the natural extracellular matrix in the human body, promoting the controlled release of growth factors and other bioactive molecules to enhance tissue regeneration and integration. Nanobioceramics mimic the structure and composition of natural bone. A major challenge in hard tissue healing is creating scaffolds that incorporate stem cells for bone tissue engineering. Scaffolds and implants for regenerative medicine should be designed using computer-aided design (CAD) and three-dimensional (3D) printing to replicate the tissue’s anatomical structure. Future studies should examine the relationship between the size of bioceramics and biological reactions. The more interacting nature of nanoceramics better triggers the cellular processes, facilitating the regeneration of calcified tissue. Osteoblasts and osteoclasts are crucial in the development and maintenance of calcified tissue in vivo, and nanoceramics enhance the functionality of orthopedic and dental implants.

References

Affatato S, Torrecillas R, Taddei P, et al., 2006 Advanced Nanocomposite Materials for Orthopaedic Applications. I. A Long-Term In Vitro Wear Study of Zirconia-Toughened Alumina. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 78(1): 76–82. https://www.doi.org/10.1002/jbm.b.30462

Arcos D, Vallet-Regi M, 2013, Bioceramics for Drug Delivery. Acta Materialia, 61(3): 890–911. http://dx.doi.org/10.1016/j.actamat.2012.10.039

Barralet JE, Grover L, Gaunt T, et al., 2002, Preparation of Macroporous Calcium Phosphate Cement Tissue Engineering Scaffold. Biomaterials, 23(15), 3063-3072. http://dx.doi.org/10.1016/S0142-9612(01)00401-X

Barrere F, Mahmood TA, de Groot K, et al., 2008, Advanced Biomaterials for Skeletal Tissue Regeneration: Instructive and Smart Functions. Materials Science and Engineering: R: Reports, 59(1): 38–71. http://dx.doi.org/10.1016/j.mser.2007.12.001

Ben-Nissan B, 2005, Biomimetics and Bioceramics, in Learning from Nature How to Design New Implantable Biomaterials: From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes. Springer, Netherlands, 89–103.

Billotte WG, 2007, Ceramic Biomaterials, CRC Press, Boca Raton, 2-1–2-34.

Liu H, Webster TJ, 2007, Nanomedicine for Implants: A Review of Studies and Necessary Experimental Tools. Biomaterials, 28(2), 354–369. http://dx.doi.org/10.1016/j.biomaterials.2006.08.049

Campbell AA, 2003, Bioceramics for Implant Coatings. Materials Today, 6(11): 26–30. http://dx.doi.org/10.1016/S1369-7021(03)01128-3

Chris Arts JJ, Verdonschot N, Schreurs BW, et al., 2006, The Use of a Bioresorbable Nano-Crystalline Hydroxyapatite Paste in Acetabular Bone Impaction Grafting. Biomaterials, 27(7): 1110–1118. http://dx.doi.org/10.1016/j.biomaterials.2005.07.024

Colon G, Ward BC, Webster TJ, 2006, Increased Osteoblast and Decreased Staphylococcus Epidermidis Functions on Nanophase ZnO and TiO2. Journal of Biomedical Materials Research Part A, 78(3): 595–604. https://doi.org/10.1002/jbm.a.30789

Dagnija L, Janis L, Kristine S, et al., 2011, Porous Hydroxyapatite Bioceramic Scaffolds for Drug Delivery and Bone Regeneration. IOP Conference Series: Materials Science and Engineering, 18(19): 192019.

Damien E, Hing K, Saeed S, et al., 2003, A Preliminary Study on the Enhancement of the Osteointegration of a Novel Synthetic Hydroxyapatite Scaffold In Vivo. Journal of Biomedical Materials Research Part A, 66(2): 241–246. https://doi.org/10.1002/jbm.a.10564

Kim HW, Kim HE, 2006, Nanofiber Generation of Hydroxyapatite and Fluor-Hydroxyapatite Bioceramics. Journal of Biomedical Materials Research Part B: Applied Biomaterials: An Official Journal of the Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 77(2): 323–328.

Dorozhkin SV, 2010, Bioceramics of Calcium Orthophosphates. Biomaterials, 31(7): 1465–1485. https://doi.org/10.1016/j.biomaterials.2009.11.050

Ducheyne P, Mauck RL, Smith DH, 2012, Biomaterials in the Repair of Sports Injuries. Nat Mater, 11(8): 652–654.

Ducheyne P, Radin S, King L, 1993, The Effect of Calcium Phosphate Ceramic Composition and Structure on In Vitro Behaviour. I. Dissolution. Journal of Biomedical Materials Research, 27(1): 25–34. https://doi.org/10.1002/jbm.820270105

Eisenbarth E, Velten D, Muller M, et al., 2004, Biocompatibility of Beta-Stabilizing Elements of Titanium Alloys. Biomaterials, 25(26): 5705–5713. https://doi.org/10.1016/j.biomaterials.2004.01.021

El-Meliegy E, van Noort R, 2012, Selection Criteria of Ceramics for Medical Applications Glasses and Glass Ceramics for Medical Applications, Springer, New York, 19–36.

Friedman CD, Costantino PD, Takagi S, et al., 1998, BoneSourceTM Hydroxyapatite Cement: A Novel Biomaterial for Craniofacial Skeletal Tissue Engineering and Reconstruction. Journal of Biomedical Materials Research, 43(4): 428–432. https://doi.org/10.1002/(SICI)1097-4636(199824)43:4<428::AID-JBM10>3.0.CO;2-0

Geetha M, Singh AK, Asokamani R, Gogia AK, 2009, Ti Based Biomaterials, the Ultimate Choice for Orthopaedic Implants – A Review. Progress in Materials Science, 54(3): 397–425. https://doi.org/10.1016/j.pmatsci.2008.06.004