Investigation of the Clinical Diagnostic Significance of the T-Cell Test for Tuberculosis combined with Erythrocyte Sedimentation Test in Pulmonary Tuberculosis
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Peripheral blood tuberculosis infection T-cell spot test
Erythrocyte sedimentation rate test
Clinical diagnosis



Submitted : 2024-02-23
Accepted : 2024-03-09
Published : 2024-03-24


Objective: To investigate the clinical diagnostic significance of peripheral blood T-cell test (T-spot test) for tuberculosis (TB) infection combined with erythrocyte sedimentation rate (ESR) in pulmonary TB. Methods: 41 patients with a clinical diagnosis of TB during hospitalization from January 2020 to April 2023 in our hospital were selected as the experimental group, and 45 patients without TB (bronchopneumonia patients) were selected as the control group. The diagnostic specificity, sensitivity, and accuracy of the T-spot TB test, ESR test, and the combined test of the two were calculated respectively. Results: The sensitivity, specificity, and accuracy of the T-spot TB test combined with ESR for the diagnosis of TB in the experimental group were significantly higher than the individual results of the T-spot TB test and ESR test alone (P < 0.05). Conclusion: The T-spot TB test combined with the ESR test for TB diagnosis has greater clinical value than carrying out the tests individually.


Zhang P, 2001, Guidelines for the Diagnosis and Treatment of Tuberculosis. Chinese Journal of Tuberculosis and Respiratory, 24(2): 70–74.

Diagnostic Criteria for Tuberculosis, n.d., 2008, WS 288-2008.

Wang L, 2006, Current Situation and Outlook of Tuberculosis Control in China. Chinese Journal of Tuberculosis and Respiratory, 2006(8): 505–506.

Ling P, Zheng J, Yan Bing, et al., 2014, Analysis of Clinical and CT Imaging Manifestations of 102 Cases of Atypical Pulmonary Tuberculosis. Journal of Clinical Radiology, 33(7): 1004–1007.

Lu P, 2018, Interpretation of the Key Points of the Latest Chinese Diagnostic Criteria for Tuberculosis. Electronic Journal of Emerging Infectious Diseases, 3(1): 57–58.

Zhou L, Liu E, 2020, “Early Diagnosis and Standardized Treatment of Tuberculosis Patients” is the Essence of Implementing the Latest National Industry Standards and Technical Specifications. Chinese Journal of Anti- Tuberculosis, 42(9): 894–895.

Su J, Xie R, Ou Y, 2021, Exploration of the Application Value of TB-DNA, IgG, IgM, and Blood Sedimentation Tests in the Diagnosis of Bacillus-Negative Pulmonary Tuberculosis. China Practical Medicine, 16(21): 69–71.

Ma L, 2021, A Study on the Significance of Adopting Ultrasensitive C-Reactive Protein and Blood Sedimentation Test for Patients with Active Pulmonary Tuberculosis. China Practical Medicine, 16(7): 70–72.

Li Q, Fang J, Xiao S, 2017, Diagnostic Value of TB-DNA, TB-Ab, Blood Sedimentation and C-Reactive Protein Measurement for Tuberculosis. China Medical Guide, 15(18): 178.

Wu Y, Wang J, Li Y, 2022, Study on the Clinical Value of Tuberculosis Infection T-Cell Assay for the Diagnosis of Pulmonary Tuberculosis. Systemic Medicine, 7(22): 100–103.

Chen M, 2021, Analysis of the Clinical Value of Tuberculosis Infection T-Cell Test for Tuberculosis Diagnosis. Primary Medical Forum, 25(11): 1574–1575.

Li G, Li Y, 2019, Clinical Application Value and Research Progress of T-Cell Detection Test for Tuberculosis Infection. International Journal of Laboratory Medicine, 40(17): 2143–2147.

Fan W, 2018, T-Cell Assay for Tuberculosis Infection Applied to Mycobacterium Tuberculosis Infection. Hebei Province, Baoding Infectious Disease Hospital.

Yang Chi, 2023, Triggers, Main Types, and Treatment of Pulmonary Tuberculosis. Health for all, 2023(3): 26–27.

Jia X, Yang J, 2018, Clinical Application of T-Cell Detection Technology for Tuberculosis Infection. Journal of Clinical Laboratory (Electronic Edition), 7(1): 134.

Meng J, Shi P, Fan W, et al., 2017, Effects of Different Storage Temperatures and Times of Peripheral Blood Samples on T-Cell Detection Results of Tuberculosis Infection. Chinese Journal of Preventive Medicine, 18(12): 906–909.