Keywords
BNDF
Bariatric surgery
Submitted : 2023-08-27
Accepted : 2023-09-11
Published : 2023-09-26
Abstract
Objectives: The rate of obesity has been increasing globally, so is the number of obese patients undergoing
bariatric surgery. The relationship between brain-derived neurotrophic factor (BDNF) and body weight has been
highlighted in recent years, but there are few related studies in China. The purpose of this study was to investigate the changes of BDNF in obese patients before and after bariatric surgery and to provide evidence for obesity-related mechanisms. Methods: The BDNF levels in 44 obese patients who underwent bariatric surgery were measured by enzyme-linked immunosorbent assay (ELISA) before and 4.5 months after surgery. SPSS 27.0 was used for statistical analysis. Results: Among the 44 patients, 30 were female and 14 were male. The body mass index (BMI) decreased significantly after bariatric surgery (P < 0.001); the serum BDNF of the patients significantly increased (P < 0.001) after surgery. There was no significant difference in BDNF among patients with different degrees of obesity before and after surgery (P > 0.05). There were no significant differences in BMI and BDNF levels between different sexes before and after surgery (P > 0.05). Conclusion: The BDNF levels of obese patients increased significantly after bariatric surgery, which proved that bariatric surgery has an effect on BDNF levels.
References
Bhupathiraju SN, Hu FB, 2016, Epidemiology of Obesity and Diabetes and Their Cardiovascular Complications. Circ Res, 118: 1723–1735.
Mohammed MS, Sendra S, Lloret J, et al., 2018, Systems and WBANs for Controlling Obesity. J Healthc Eng, 2018: 1564748.
Wang Y, Xue H, Sun M, et al., 2019, Prevention and Control of Obesity in China. Lancet Glob Health. 7(9): e1166–e1167.
Pan XF, Wang L, Pan A, 2021, Epidemiology and Determinants of Obesity in China. Lancet Diabetes Endocrinol, 9(6): 373–392.
Roth AE, Thornley CJ, Blackstone RP, 2020, Outcomes in Bariatric and Metabolic Surgery: An Updated 5-Year Review. Curr Obes Rep, 9(3): 380–389.
Chao MV, Rajagopal R, Lee FS, 2006, Neurotrophin Signalling in Health and Disease. Clin Sci (Lond), 110(2): 167–173.
Briana DD, Malamitsi-Puchner A, 2018, Developmental Origins of Adult Health and Disease: The Metabolic Role of BDNF from Early Life to Adulthood. Metabolism, 81: 45–51.
Faramia J, Ostinelli G, Drolet-Labelle V, et al., 2020, Metabolic Adaptations After Bariatric Surgery: Adipokines, Myokines and Hepatokines. Curr Opin Pharmacol, 52: 67–74.
Marosi K, Mattson MP, 2014, BDNF Mediates Adaptive Brain and Body Responses to Energetic Challenges. Trends Endocrinol Metab, 25(2): 89–98.
Wang C, Bomberg E, Billington CJ, et al., 2010, Brain-Derived Neurotrophic Factor (BDNF) in the Hypothalamic Ventromedial Nucleus Increases Energy Expenditure. Brain Res, 1336: 66–77.
Unger TJ, Calderon GA, Bradley LC, et al., 2007, Selective Deletion of BDNF in the Ventromedial and Dorsomedial Hypothalamus of Adult Mice Results in Hyperphagic Behavior and Obesity. J Neurosci, 27(52): 14265–14274.
Bumb JM, Bach P, Grosshans M, et al., 2021, BDNF Influences Neural Cue-Reactivity to Food Stimuli and Food Craving in Obesity. Eur Arch Psychiatry Clin Neurosci, 271(5): 963–974.
Celik Guzel E, Bakkal E, Guzel S, et al., 2014, Can Low Brain-Derived Neurotrophic Factor Levels be a Marker of the Presence of Depression in Obese Women? Neuropsychiatr Dis Treat, 10: 2079–2086.
Alomari MA, Khabour OF, Alawneh K, et al., 2020, The Importance of Physical Fitness for the Relationship of BDNF with Obesity Measures in Young Normal-Weight Adults. Heliyon, 6(3): e03490.
Corripio R, Gónzalez-Clemente JM, Jacobo PS, et al., 2012, Plasma Brain-Derived Neurotrophic Factor in Prepubertal Obese Children: Results from A 2-Year Lifestyle Intervention Programme. Clin Endocrinol (Oxf), 77(5): 715–720.
Lommatzsch M, Zingler D, Schuhbaeck K, et al., 2005, The Impact of Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma. Neurobiol Aging, 26(1): 115–123.
Gajewska E, Sobieska M, ?ojko D, et al., 2014, Obesity Itself Does Not Influence BDNF Serum Levels in Adults. Eur Rev Med Pharmacol Sci, 18(21): 3246–3250.
Suwa M, Kishimoto H, Nofuji Y, et al., 2006, Serum Brain-Derived Neurotrophic Factor Level Is Increased and Associated with Obesity in Newly Diagnosed Female Patients with Type 2 Diabetes Mellitus. Metabolism, 55(7): 852–857.
Taha MA, Al-Maqati TN, Alnaam YA, et al., 2022, The Association between Brain-Derived Neurotrophic Factor (BDNF) Protein Level and Body Mass Index. Medicina (Kaunas), 59(1): 99.
Glud M, Christiansen T, Larsen LH, et al., 2019, Changes in Circulating BDNF in Relation to Sex, Diet, and Exercise: A 12-Week Randomized Controlled Study in Overweight and Obese Participants. J Obes, 2019: 4537274.