Keywords
Low-dose Betaloc
Amiodarone
Submitted : 2023-08-27
Accepted : 2023-09-11
Published : 2023-09-26
Abstract
Objective: To explore and analyze the clinical effect of small and medium doses of Betaloc combined with
amiodarone in the treatment of ventricular arrhythmia. Methods: 60 patients with ventricular arrhythmia that were treated in the Department of Cardiology of our hospital from May 2018–May 2023 were selected for this study, and they were divided into a research group (n = 30) and a reference group (n = 30). The study group was treated with small doses of Betaloc and amiodarone, while the reference group was treated with conventional treatment. The total efficacy of medication, QRS interval, standard deviation of normal-to-normal (NN) intervals (SDNN), root mean square of successive differences between normal heartbeats (RMSSD), standard deviation of the average NN intervals (SDANN), and incidence of adverse reactions were compared between the groups. Results: The effectiveness of medication in the study group was significantly higher than that in the reference group (P < 0.05). Besides, there was no statistically significant difference (P > 0.05) in the QRS interval and SDNN between the two groups before treatment. After treatment, the QRS interval and SDNN of the study group were significantly lower than those of the reference group (P < 0.05). Before treatment, there was no significant difference in RMSSD and SDANN between groups (P > 0.05). After treatment, RMSSD and SDANN in the study group were significantly better than those in the reference group (P < 0.05), and the difference was statistically
significant. The incidence of adverse reactions in the study group was significantly lower than that in the reference group (P < 0.05), and the difference was statistically significant. Conclusion: Small doses of Betoprolol and amiodarone is more effective in the treatment of ventricular arrhythmia, which has the value of popularization and application.
References
Ye W, Liu X, Zhao M, et al., 2023, Correlation Between Serum hs-CRP and sST2 Levels in Patients with Chronic Heart Failure and Ventricular Arrhythmia after Cardiac Resynchronization Therapy. Difficult Diseases Journal, 22(06): 566–571 + 577.
Guo Z, Li Y, 2023, The Effect of Zhigancao Decoction Combined with Metoprolol and Amiodarone in the Treatment of Qi Deficiency and Blood Stasis Type Coronary Heart Disease Complicated with Ventricular Arrhythmia and its Effect on Vascular Endothelial Function and QT Interval Dispersion. Clinical Medicine Research and Practice, 8(01): 118–120.
Lan X, Mei L, 2022, Clinical efficacy and safety of Freeze-Dried Recombinant Human Brain Natriuretic Peptide in the Treatment of Ischemic Cardiomyopathy with Ventricular Arrhythmia and Acute Heart Failure. Clinical Rational Drug Use, 15(27): 63–66.
Zhang J, Liu W, 2022, Clinical Effect of Potassium Magnesium Aspartate Combined with Amiodarone in the Treatment of Ventricular Arrhythmia in Acute Myocardial Infarction and its Impact on Cardiac Function. Clinical Medicine Research and Practice, 7(26): 57–60.
Li J, 2022, The Curative Effect of Metoprolol Combined with Amiodarone and Atorvastatin in the Treatment of Patients with Ventricular Arrhythmia After Myocardial Infarction and Analysis of Serum Inflammatory Factor Levels. Clinical Research, 30(04): 78–81.
Qiu D, 2021, Clinical Effect of Irbesartan Hydrochlorothiazide Combined with Bisoprolol in the Treatment of Patients with Chronic Heart Failure Complicated with Atrial or Ventricular Arrhythmia. China Contemporary Medicine, 28(31): 63–66.
Xu Z, 2021, Efficacy of Potassium Magnesium Aspartate Injection Assisted Trimetazidine Sustained Release Tablets in the Treatment of Patients with Ventricular Arrhythmia and its Effect on Heart Rate Variability. Medical Equipment, 34(18): 133–134.
Zhang S, Zhu F, Ma Y, 2021, Effects of Amiodarone Combined with Creatine Phosphate Sodium on Cardiac function Indexes and Serum NF-?B and CD40L Levels in Patients with Ventricular Arrhythmia. Journal of Clinical and Experimental Medicine, 20(18): 1948–1951.
Ma Y, 2021, Observation on Curative Effect of Tongbi Ningxin Decoction Combined with Mexiletine in The Treatment of Ventricular Arrhythmia in Coronary Heart Disease and its Influence on HRV, Qtd and Left Ventricular Remodeling. Sichuan Traditional Chinese Medicine, 39(06): 72–76.
Bai Y, An G, Zhao D, 2021, The Effect of PCI Combined with Intracoronary and Intravenous Injection of Tirofiban in the Treatment of Acute Myocardial Infarction and its Impact on the Incidence of Malignant Ventricular Arrhythmia. Clinical Medicine, 41(04): 32–34.
Wang C, Wu Q, Xu M, et al., 2020, Effect of PCI Combined with Intracoronary Tirofiban Therapy on The Incidence and Clinical Efficacy of Malignant Ventricular Arrhythmia in Patients with AMI. Guangdong Medicine, 41(16): 1702–1705.
Huang Y, Gu J, Wu Y, 2021, The Curative Effect of Yangxin Fuli Decoction in the Treatment of Heart Failure Complicated with Ventricular Arrhythmia and its Influence on Heart Rate Variability and QT Dispersion. Chinese Medicine Emergency, 30(02): 297–300.
Ma Y, 2021, Efficacy of Oryzanol Tablets Combined with Amiodarone and Potassium Magnesium Aspartate in the Treatment of Heart Failure with Ventricular Arrhythmia in Elderly Patients with Chronic Ischemic Cardiomyopathy. Practical Integrative Medicine of Traditional Chinese and Western Medicine, 21(02): 15–16 + 39.
Hu N, 2020, The Curative Effect of Metoprolol Combined with Shensong Yangxin Capsules in the Treatment of Stable Angina Pectoris Complicated with Ventricular Arrhythmia and the Analysis of its Influence on the Level of Myocardial Enzyme Spectrum. Chinese Journal of Practical Rural Doctors, 27(12): 56–58.
Qian J, Wang X, 2020, Clinical Analysis of Amiodarone and Metoprolol Combined Therapy on Cardiac Function, Sinus Rhythm Maintenance and Safety in Emergency Patients with Chronic Heart Failure Complicated with Ventricular Arrhythmia. North Pharmacy, 17(11): 122–123.