Research Progress on Mechanisms in Regulating Anxiety-Related Neural Circuits
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Keywords

Anxiety
Basal lateral amygdala (BLA)
Bed nucleus of stria terminalis (BNST)
Ventral tegmental area (VTA)
Brain

DOI

10.26689/jcnr.v7i1.4573

Abstract

Anxiety is a common disease in the modern society which significantly affects people’s daily lives and function, thus it has become an increasingly highlighted issue. Anxiety is regulated by neural circuits in the brain. Therefore, the basal mechanism of anxiety has been studied, especially research based on the related neural circuits. For a long time, due to the limitations of science and technology, there was no breakthrough in research regarding anxiety. However, in recent years, due to the progress of technology, the research on anxiety neural circuits has made great progress. For example, the interaction among various brain regions, such as the central nucleus of the amygdala (CeA), the ventral tegmental area (VTA), the ventral hippocampus (vHPC), and so on. This article focuses on three brain regions: including BLA, BNST, and VTA, and illustrate their different roles and mechanisms in regulating anxiety. On this basis, this intensive study of anxiety will further promote the progress of anxiety research and provide therapeutic targets for the related treatment.

References

Dean E, 2016, Anxiety. Nurs Stand, 30(46): 15.

Bandelow B, Michaelis S, 2015, Epidemiology of Anxiety Disorders in the 21st Century. Dialogues Clin Neurosci, 17(3): 327–335.

Tiller JW, 2013, Depression and Anxiety. Med J Aust, 199(S6): S28-S31.

Felix-Ortiz AC, Burgos-Robles A, Bhagat ND, et al., 2016, Bidirectional Modulation of Anxiety-Related and Social Behaviors by Amygdala Projections to the Medial Prefrontal Cortex. Neuroscience, 321: 197–209.

Hur J, Stockbridge MD, Fox AS, Shackman AJ, 2019, Dispositional Negativity, Cognition, and Anxiety Disorders: An Integrative Translational Neuroscience Framework. Prog Brain Res, 247: 375–436.

Botta P, Demmou L, Kasugai Y, et al., 2015, Regulating Anxiety with Extrasynaptic Inhibition. Nature Neuroscience, 18(10): 1493–1500.

Avery SN, Clauss JA, Blackford JU, 2016, The Human BNST: Functional Role in Anxiety and Addiction. Neuropsychopharmacology, 41(1): 126–141.

Kim SY, Adhikari A, Lee SY, et al., 2013, Diverging Neural Pathways Assemble a Behavioural State from Separable Features in Anxiety. Nature, 496(7444): 219–223.

Morel C, Montgomery SE, Li L, et al., 2022, Midbrain Projection to the Basolateral Amygdala Encodes Anxiety-Like but not Depression-Like Behaviors. Nature Communications, 13(1): 1–13.

Qi G, Zhang P, Li T, Li, M., et al., 2022, NAc-VTA Circuit Underlies Emotional Stress-Induced Anxiety-like Behavior in the Three-Chamber Vicarious Social Defeat Stress Mouse Model. Nature Communications, 13(1): 1–19.

Lammel S, Lim BK, Malenka RC, 2014, Reward and Aversion in a Heterogeneous Midbrain Dopamine System. Neuropharmacology, 76: 351–359.

Bouarab C, Thompson B, Polter AM, 2019, VTA GABA Neurons at the Interface of Stress and Reward. Frontiers in Neural Circuits, 13: 78.

Creed MC, Ntamati NR, Tan KR, 2014, VTA GABA Neurons Modulate Specific Learning Behaviors Through the Control of Dopamine and Cholinergic Systems. Frontiers in Behavioral Neuroscience, 8: 8.

Tye KM, Prakash R, Kim SY, et al., 2011, Amygdala Circuitry Mediating Reversible and Bidirectional Control of Anxiety. Nature, 471(7338): 358–362.

Ch'ng S, Fu J, Brown RM, et al., 2018, The Intersection of Stress and Reward: BNST Modulation of Aversive and Appetitive States. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 87: 108–125.

Morel C, Montgomery SE, Li L, et al., 2022, Midbrain Projection to the Basolateral Amygdala Encodes Anxiety-Like but not Depression-Like Behaviors. Nature Communications, 13(1): 1–13.

Sah P, 2017, Fear, Anxiety, and the Amygdala. Neuron, 96(1): 1–2.