A Meta-Analysis on the Correlation Between Herpes Simplex Virus Type II Infection and Adverse Pregnancy Outcomes in China
Download PDF


Herpes simplex virus type II
Adverse pregnancy outcomes



Submitted : 2022-12-17
Accepted : 2023-01-01
Published : 2023-01-16


Objective: To systematically evaluate the relationship between herpes simplex virus type II (HSV-2) infection in pregnant women and the adverse pregnancy outcomes (preterm delivery, spontaneous abortion, stillbirth, monstrum, low birth weight, intrauterine growth retardation, premature rupture of membranes), so as to provide clinical guidance for the prevention and treatment of adverse pregnancy outcomes caused by HSV-2 infection in pregnant women. Methods: 2140 articles were collected from PubMed, China National Knowledge Infrastructure (CNKI), and other databases for the past 20 years. According to the inclusion criteria, the literatures about the relationship between HSV-2 infection of pregnant women and adverse pregnancy outcomes were screened. The effect model was determined by heterogeneity test results, and the meta-analysis was carried out by RevMan 5.3 software. Results: The results of meta-analysis showed that the positive rate of HSV-2 was higher in the adverse pregnancy group than in the control group (odds ratio [OR]: 7.92, 95% confidence interval [Cl]: 3.91–16.01), and the difference was statistically significant. Conclusion: HSV-2 infection will increase the risk of adverse pregnancy outcomes. Prevention and effective control of HSV-2 infection in early pregnancy can reduce the rate of adverse pregnancy outcome, which is of great significance to the promotion of eugenics.


Ryan KJ, Ray CG, 2004, Sherris Medical Microbiology, 4th Edition, McGraw Hill.

HSV-1 and 2 Assay for the Detection of HSV in Cutaneous and Mucocutaneous Lesion Specimens. J Clin Virol, 99–100:1–4?

Sonia B, David B, Diane R, et al., 2017, Ancient Recombination Events Between Human Herpes Simplex Viruses. Mol Biol Evol, 34(7): 1713–1721.

Petro C, Gonzalez P A, Cheshenko N, et al., 2015, Herpes Simplex Type 2 Virus Deleted in Glycoprotein D Protects Against Vaginal, Skin and Neural Disease. eLife, 4(4): 1-18.

Chen P, Ma L, Liu E, et al., 2015, Epidemiological Characteristics of Herpes Simplex Virus Type 2 Infection in Different Populations. International Journal of Biological Products, 38(4): 189–192.

Looker KJ, Magaret AS, Turner KM, et al., 2015, Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012. PLoS One, 10(1): e114989.

Bradley H, Markowitz LE, Gibson T, et al., 2014, Seroprevalence of Herpes Simplex Virus Types 1 and 2 United States, 1999-2010. J Infect Dis, 209(3): 325–333.

Looker KJ, Garnett GP, Schmid GP, 2008, An Estimate of the Global Prevalence and Incidence of Herpes Simplex Virus Type 2 Infection. Bull World Health Organ, 2008, 86(10): 805–812.

Smith JS, Robinson NJ, 2002, Age-Specific Prevalence of Infection with Herpes Sim-Plex Virus Types 2 and 1: A Global Review. J Infect Dis, 186, Suppl 1: S3–S28.

World Health Organization, 2007, Global Strategy for the Prevention and Control of Sexually Transmitted Infections: 2006-2015: Breaking the Chain of Trans-Mission, World Health Organization, Geneva.

Yue X, Fu Q, Fu Y, 2017, Meta-Analysis of the Relationship Between Simple Hypothyroidism and Adverse Pregnancy Outcomes. Journal of Preventive Medicine of the PLA, 9: 1098–1102.

Wu C, Qiu M, 2015, Analysis of Adverse Pregnancy and HSV-2 IgM IgG Antibody Detection Results. Hainan Medical Journal, 1: 133–134.

Luo H, Du X, Liu C, et al., 2005, Effect of Herpes Simplex Virus Infection on Pregnant Women and Fetuses. Sichuan Medical Journal, 3: 302–303.

Shen S, Liu F, Liu M, 2004, Analysis of Cytomegalovirus Antibody, Herpes Simplex Virus Antibody and Toxoplasma Antibody in pregnant women with Spontaneous Abortion. Heilongjiang Medical Journal, 10: 775–776.

Chen Y, 2014, Analysis of 1876 TORCH Test Results. Chinese Journal of Laboratory Diagnostics, 12: 2052–2054.

Li K, Zhou H, 2018, Study on the Correlation Between TORCH Infection and Pregnancy Outcome of Pregnant Women. Chinese Journal of Eugenics and Genetics, 5: 65–66.

Han Q, Zhou W, Duan L, et al. 2008, Study on the Relationship Between TORCH Infection and Premature Delivery of Pregnant Women. Chinese Journal of Eugenics and Genetics, 8: 84

Xu N, 2016, Analysis of Related Factors Between TORCH Infection and Spontaneous Abortion. Chinese Medical Guide, 35: 169–170.

Ling W, Xie S, Pan G, et al., 2016, Study on the Correlation Between TORCH Series Pathogenic Microorganism Infection and Premature Delivery. China Contemporary Medicine, 8: 95–97.

Yang Y, Yu L, Zhang L, et al., 2000, Study on the Relationship Between Adverse Pregnancy and TORCH Infection. Journal of Ningxia Medical College, 22(06): 407–408.

Yao J, 2019, Clinical Observation on TORCH Serological Detection and Pregnancy Outcome in Pregnant Women. Modern Practical Medicine, 8: 1086–1087.

Luo L, Feng Y, Guo Z, et al., 2006, Pregnancy and TORCH Infection. Journal of Kunming Medical College, 2: 78–81.

Hu J, 2013, Study on the Correlation Between Habitual Abortion and TORCH Infection. Chinese Journal of Hospital Infection, 1: 106–107.

Song Z, Lv B, Zhang A, 2002, Effect of TORCH Infection in Pregnant Women on Fetus. Chinese Journal of Eugenics and Genetics, 3: 72–73.

Wang R, Fan W, Liu Z, 2013, Study on the Correlation Between Premature Delivery and TORCH Infection in Pregnant Women. Journal of Practical Medicine, 14: 2413-2414.

Li S, 2007, Pathogen Detection of Early Abortion and Premature Pregnancy. Guangxi Medical Journal, 4: 496–497.

Liu L, 2018, TORCH Examination Results of Women Before Pregnancy and Early Pregnancy in Chang’an District and its Relationship with Adverse Pregnancy Outcomes. Clinical Medical Research and Practice, 28: 138–139.

Lu B, 2016, Analysis of TORCH Test Results in Patients with Spontaneous Abortion. Journal of Community Medicine, 19: 75–76.

Yan H, Su D, Zhao Y, et al., 2007, Research Status of Genital Herpes and Ethical Issues in Diagnosis and Treatment. Medicine and Philosophy (Clinical Decision Forum), 5: 68–70.

Lai W, Shao C, 1996, Epidemiology and Risk Factors of Genital Herpes. Journal of Dermatology and Venereology of Foreign Medicine, 22(5): 261–265.