Keywords
Progesterone
Early pre-eclampsia miscarriage
Application effect
Sex hormone level
Inflammatory factor
Submitted : 2022-08-30
Accepted : 2022-09-14
Published : 2022-09-29
Abstract
Objective: To investigate the clinical efficacy of the combination of enhanced “Shou Tai Wan” soup and progesterone in the treatment of early pre-eclampsia miscarriage. Methods: 86 patients with early pre-eclampsia miscarriage in our hospital from July 2021 to July 2022 were selected and randomly divided into two groups of 43 cases each. The control group was treated with progesterone, while the study group was treated with an addition of enhanced “Shou Tai Wan” soup. The treatment effects of the two groups and the changes in the inflammatory factor levels and sex hormone levels before and after the treatment were observed. Results: INF-? and Il-2 were lower and IL-4 was higher in the study group than in the control group after treatment (p-value < 0.05); the total effective rate of treatment was higher in the study group (95.35%) than in the control group (74.42%), (p-value < 0.05); the levels of P, E2 and ?-hCG were higher in the study group than in the control group after treatment (p-value < 0.05). Conclusion: The combined application of enhanced “Shou Tai Wan” soup and progesterone in patients with early preterm abortion is more effective by improving the patients’ sex hormone levels and reducing the level of inflammatory factors, which is conducive to the improvement of the treatment effect and worthy of promotion.
References
Wu Y, Fu Y, Cai Y, 2020, Efficacy of Zi He Che Combined with Enhanced ‘Shou Tai Wan’ in the Treatment of Low Estrogen Pre-Eclampsia After Frozen Embryo Transfer. Journal of Modern Traditional Chinese and Western Medicine, 29(5): 538–541.
Liu S, Li F, Liu Z, et al., 2021, Meta-Analysis of the Efficacy of Mebendazole Combined with Progesterone in the Treatment of Preterm Abortion Before 20 Weeks of Gestation. Chinese Family Planning and Obstetrics and Gynecology, 13(5): 67–73.
Zhang Y, Kang X, Hao W, et al., 2022, Effects of Dydrogesterone Combined with Oral Progesterone Pills on Serum Inhibin A and Sex Hormones in Patients with Luteal Insufficiency and Preterm Abortion. Modern Biomedical Advances, 22(4): 669–673.
Mi Y, Li X, You J, et al., 2021, Effect of Solid Yuan Fetal Stabilization Soup Combined with Progesterone on Serum Sex Hormones and MCP-1 and IL-1? Levels in Patients with Preterm Abortion. New Drugs in Chinese Medicine and Clinical Pharmacology, 32(1): 123–127.
Zhang Q, Zeng QD, Yin QY, 2020, Effect of Low-Dose Progesterone Injection Combined with Fetal Protection Capsule on Serum P, E2, and ?-hCG in Women with Preterm Abortion. China Medicine Herald, 17(27): 112–115.
Yan X, Lu Y, 2020, Study on the Effect of Combining Progesterone with Warm Kidney and Fetus Soup on Endocrine Levels And T-Lymphocyte Subpopulation Factors in Preterm Abortion. Chinese Journal of Traditional Chinese Medicine, 38(6): 229–232.
Xie Y, Yuan X, 2020, Effects of Progesterone Combined with Dydrogesterone on Serum Human Chorionic Gonadotropin, Progesterone Levels and Pregnancy Outcome in Patients with High-Grade Preterm Abortion. Chinese Journal of Clinical Pharmacy, 29(6): 414–418.
Yang M, Luo J, Yang Q, et al., 2021, Research on the Medication Rules of Chinese Herbal Formulas on Treatment of Threatened Abortion. Complementary Therapies in Clinical Practice, 43(2): 101371.
Lai XL, Sun Y, 2020, Effect of Dydrogesterone Combined with Progesterone on the Success Rate of Second-Trimester Pre-Eclampsia and the Levels of ?-hCG, Progesterone and Estrogen in Advanced Age. Chinese Sex Science, 29(8): 42–44.
Valley MT, 2020, Mifepristone Antagonization with Progesterone to Prevent Medical Abortion: A Randomized Controlled Trial. Obstetrics and Gynecology, 135(4): 970.
Xu CM, Wu XR, Zhou MT, et al., 2020, Efficacy of Wentong Cream Applied Externally Combined with Infrared Irradiation in the Treatment of Local Reactions Caused by Intramuscular Progesterone and The Effect on Patients’ Immune Function. Shaanxi TCM, 41(8): 1121–1124.
Ataide GA, Kloster A, Moraes M, et al., 2021, Early Resynchronization of Follicular Wave Emergence Among Nelore Cattle Using Injectable and Intravaginal Progesterone for Three–Timed Artificial Inseminations. Animal Reproduction Science, 229(8): 106759.
Liu W, Jiang J, 2022, Effect of Supplemental Treatment with Kidney Nourishing Formula on Symptom Scores, Sex Hormone Levels and Pregnancy Outcome in Pregnant Women with Kidney-Deficient High-Grade Preterm Abortion in Early Pregnancy. Hainan Medicine, 33(4): 459–463.
Xiao J, Zhang W, Huang M, et al., 2021, Increased Risk of Multiple Pregnancy Complications Following Large-Scale Power Outages During Hurricane Sandy in New York State. Science of the Total Environment, 770(6): 145359.
Pakniat H, Ansari I, Kashanipour N, et al., 2021, Effect of Vaginal Progesterone and Dydrogesterone on Pregnancy Outcomes in patients with Threatened Abortion: A Randomized Clinical Trial. Iranian Journal of Obstetrics, Gynecology and Infertility, 24(1): 18–25.