Comparison on the Perinatal Complications for Newborns between by IVF-ET and Natural Delivery


Test tube baby
Newborn of natural delivery
Perinatal stage




This study was conducted to compare the perinatal complications for newborns by In vitro fertilization with embryo transfer (IVF-ET) and natural delivery. Respectively 50 cases of the IVF-ET and 50 cases of the natural delivery were selected from Hospital of Chengde Medical University as research subjects. All the recruited cases were selected with the newborns from April, 2021 to April, 2022. Defining the IVF-ET as the test group, while the natural delivery as the control group to compare and analyze the perinatal situations and the incidences of complications in both the groups. This study showed that the incidences of pregnancy-induced hypertension, diabetes, multiple pregnancy, premature delivery, and cesarean section in the test group were significantly (p<0.05) higher, than the control group. In addition, the incidences of neonatal respiratory distress syndrome (NRDS) and hyperbilirubinemia of newborns in the test group were statistical (p<0.05) higher, compared to the control group. In contrast, there are no statistically significant differences in terms of hypoglycemia, pneumonia, and neonatal asphyxia incidences between the two groups (p>0.05). Interestingly, there is a significant difference (p<0.05) in the incidences of neonatal cardiac anomalies in both groups, however, no significant differences (p>0.05) were observed in terms of birth defects including hypospadias, the cleft lip and palate, polydactyly, anal atresia, and esophageal atresia in both the groups. In summary, the test tube babies of IVF-ET are more susceptible to complications in their perinatal stage compared with natural delivery newborns, therefore, during the clinical development physicians should strengthen clinical attention and take proactive healthcare management, in order to maintain the health and life of the newborns.


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