Keywords
Acute mammary mastitis
Milk carbuncle
Meta analysis
Submitted : 2021-12-25
Accepted : 2022-01-09
Published : 2022-01-24
Abstract
Objective: To systematically evaluate the clinical efficacy of Gualou Niubang decoction in the treatment of acute mastitis. Methods: Randomized controlled trials of Gualou Niubang decoction in the treatment of acute mastitis included in PubMed, Springer, Embase, Cochrane Library, CNKI, Wanfang, Weipu, and China Biomedical Literature Database from January 2016 to present. The Cochrane risk bias assessment tool was used to evaluate the risk of bias. Used Revman 5.3 software for Meta analysis. Results: There are 8 articles that meet the inclusion criteria, comprising 919 subjects, the test group were 462, cases and control group were 457 cases. The results of statistical analysis showed that the clinical efficacy of the experimental group was significantly higher than which of the control group, [RR = 1.19, 95% CI (1.07, 1.33), P = 0.002], the difference was statistically significant. Among the secondary outcome indicators, compared to the control group, Gualou Niubang decoction can effectively relieve the main symptoms of acute mastitis [MD = -1.96, 95% CI (-2.27, -1.65), P<0.0001]. Gualou Niubang decoction combined with antibiotics can shorten the length of hospital stay [MD=-5.23,95% CI (-6.02, -4.44), P<0.00001] and reduce white blood cell count [MD = -2.40, 95%CI (-4.71, -0.08), P = 0.04] are better than antibiotics. Conclusion: The use of Gualou Niubang decoction to treat acute mastitis can not only improve clinical efficacy, but also effectively relieve clinical symptoms, shorten hospital stay and reduce white blood cell count.
References
Zhu XQ, Mi HX, Lin X, et al., 2017, Effect of Gualou Niubang Decoction Combined with Yanghe Decoction Combined with External Application of Traditional Chinese Medicine on the Levels of IL-6 and CRP in Early Lactation Patients with Acute Mastitis. Chinese Archives of Tradtional Chinese Medicine, 35(4): 819-821.
Peng FH, Yun HX, 2014, Clinical Observation on 43 Cases of Acute Mastitis Treated by Oral and External Application of Traditional Chinese Medicine. Herald of Traditional Chinese Medicine, 20(14): 70-71.
Guo HY, Wang EL, Zhong CE, 2015, Effect Observation and Nursing of Self-Made Chinese Medicine External Application in Adjuvant Treatment of Lactation Acute Mastitis. Nursing Practice and Research, 12(5): 145-146.
Liu S, Zhao HM, Gao Y, 2019, The Effect of the Combined Application of Gualou Niuang Decoction and Yanghe Decoction with External Application of Traditional Chinese Medicine on the Levels of Inflammatory Mediators and TCM Syndrome Scores in Patients with Acute Mastitis During Lactation. China Pharmacoeconomics, 14(11): 110-112+116
Qi J, Zhang YF, Xia QQ, 2015, Erchen Decoction in the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review. Liaoning Journal of Traditional Chinese Medicine, 31(212): 2276-2280.
Higgins JP, Thompson SG, 2002, Quantifying Heterogeneity in a Meta-Analysis. Stat Med, 21(11): 1539-1558.
Higgins JPT, Ompson SG, et al., 2003, “Measuring Inconsistency in Meta-Analysis,” BMJ, 327(7414): 557–560,2003.
Yin LX, 2018, Clinical Effect Analysis of Modified Gualou Niubang Decoction Combined with Milk Excretion in the Treatment of Lactation Mastitis. China's Rural Health, (15): 68+67.
Cai GY, Yang LC, 2016, Clinical Observation of Effects of Modified Gualou Niubang Decoction on Early-Stage Acute Mastitis During Lactation. Shanghai Journal of Traditional Chinese Medicine, 50(12): 57-59.
Xu XQ, et al., 2016, Clinical Research of Modified Gualou Niubang Decoction Combined with Milk Ejection Method in Treating Lactation Mastitis. Clinical Journal of Chinese Medicine, 8(03): 73-75.
Wu XB, 2016, Clinical Observation of Gualou Niubang Decoction in the Treatment of Acute Mastitis. Chinese Medicine Modern Distance Education of China, 2016. 14(12): 92-93.
Cao YN, Fan W, Wang H, 2016, Gualou Niubang Decoction Combined with Western Medicine in the Treatment of Early Acute Mastitis Analysis of the Curative Effect and Prognosis of the Patients. Journal of Emergency in Traditional Chinese Medicine, 25(11): 2158-2160.
Wang RH, Huang, 2017, Clinical Effect Observacation of Gualou Niubang Decocation in the Treatment of Acute Mastitis in Lavtation Period. Shaanxi Journal of Traditional Chinese Medicine, 38(07): 823-824.
Dong WQ, Chen DJ, 2018, Effect of Modified Gualou Niubang Decoction in the Treatment of Lactation Mastitis. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 28(24): 32-34.
Wang XJ, 2019, Clinical Study on the Treatment of Acute Suppurative Mastitis with Gualou Niubang Decoction Combined with Small Needle Knife Therapy. Henan Traditional Chinese Medicine, 39(06): 910-913.
Lv JQ, Yang JJ, Gong XN, et al., 2014, Clinical Observation of Acute Suppurative Mastitis Complicated with Severe Infection During Pregnancy. Maternal and Child Health Care of China, 29(015): 2404-2405.
Xia HL, Yang LC, 2011, Risk Factors of Puerperal Mastitis. Anhui Medical and Pharmaceutical, 15(12): 1522-1524.
Harris, 2006, Mammology USA, Shandong Science and Technology Press, Jinan, 3: 51.
Zhou M, Lin X, Cheng YQ, et al., 2009, A Randomized Controlled Clinical Study on the Treatment of Acute Mastitis by Kneading Powder. Journal of Integrated Chinese and Western medicine, 7(12): 1130-1133.
Gu BH, 1994, Practical Surgery of Traditional Chinese Medicine, Shanghai Scientific and Technical Publishers, Shanghai, 129.
Meng JC, 2019, Clinical Observation on the Treatment of Mastitis (Stagnation) in Lactation with Gualou Niubang Decoction and Massage. Guangming Traditional Chinese Medicine, 34(15): 2356-2357.
Jing YS, Wan H, 2016, Treatment of Acne Mastitis by Clearing Phlegm Dampness Combined with External Therapy. Jilin Traditional Chinese Medicine, 36(6): 583-585.
Guo CM, Fu MG, Li D, et al., 2015, Clinical Analysis of 138 Cases of Non-Lactation Mastitis. Medical Review, 21(6): 1106-1107.